Pharmaceutical studies on ligustilide

Pao Yue-kong Library Electronic Theses Database

Pharmaceutical studies on ligustilide

 

Author: Wang, Chengyuan
Title: Pharmaceutical studies on ligustilide
Degree: Ph.D.
Year: 2008
Subject: Hong Kong Polytechnic University -- Dissertations.
Angelica -- Therapeutic use.
Medicinal plants.
Department: Dept. of Applied Biology and Chemical Technology
Pages: 312 leaves : ill. (some col.) ; 30 cm.
Language: English
InnoPac Record: http://library.polyu.edu.hk/record=b2239718
URI: http://theses.lib.polyu.edu.hk/handle/200/1205
Abstract: Ligustilide (LIG) is the main effective component in Angelica sinensis (當歸) and Ligusticum chuanxiong (川芎). Previous studies had shown that LIG had significant pharmacological effects on cerebral blood vessels, the general circulatory system and immune system. LIG in the medicinal materials has two configurations, Z-ligustilide (Z-LIG) and E-ligustilide (E-LIG). Z-LIG is the main configuration. However, since LIG has a poor stability, it is very difficult to prepare and preserve it. Therefore, the study of LIG has been limited and so far is not comprehensive and systematic. In this thesis, we seek solutions for these problems. In the first series of experiments we systematically examined the content of LIG in Angelica sinensis and Ligusticum chuanxiong, and found that the former is the better source of LIG. We then systematically extract and isolate LIG in Angelica sinensis volatile oil (ASVO), and discovered a new isolation method of LIG that is suitable for industrial production. A patent has been granted for this new isolation method, which produces high purity LIG that could be used as the standard and also the raw material for a new medicine in first category. We also tried to increase the yield of synthesis of LIG but the yield was too low for larger scale industrial production. In the second series of experiments we characterized the physical and chemical properties as well as the stability of LIG systematically based on the high purity LIG. We also searched for specific stabilizer or any factor that could increase the stability of LIG. Based on these experiments we developed the highly stable LIG which could be used as the standard in the industrial production. Furthermore, we developed cyclodextrin (CD) inclusion complex-based and micro-emulsion (ME) of LIG preparations, with enhanced stability of LIG in both preparations, laying the foundation for the development of different LIG preparations. Finally we studied the acute toxicity of LIG, which was found to be low and complied with the safety requirement of new medicine. Therefore, LIG has good potential to be developed into a new first category medicine in the future. This thesis consists of 11 chapters, beginning with a general introduction, and then followed by the methodology section. There are then eight chapters on results, and at the end, there is a general discussion.

Files in this item

Files Size Format
b22397188.pdf 2.761Mb PDF
Copyright Undertaking
As a bona fide Library user, I declare that:
  1. I will abide by the rules and legal ordinances governing copyright regarding the use of the Database.
  2. I will use the Database for the purpose of my research or private study only and not for circulation or further reproduction or any other purpose.
  3. I agree to indemnify and hold the University harmless from and against any loss, damage, cost, liability or expenses arising from copyright infringement or unauthorized usage.
By downloading any item(s) listed above, you acknowledge that you have read and understood the copyright undertaking as stated above, and agree to be bound by all of its terms.

     

Quick Search

Browse

More Information