A review of stereotactic radiotherapy booster after conventional radiotherapy for Ho's T3 nasopharyngeal carcinoma

Pao Yue-kong Library Electronic Theses Database

A review of stereotactic radiotherapy booster after conventional radiotherapy for Ho's T3 nasopharyngeal carcinoma

 

Author: Mak, King-chung Anthony
Title: A review of stereotactic radiotherapy booster after conventional radiotherapy for Ho's T3 nasopharyngeal carcinoma
Degree: M.Sc.
Year: 2001
Subject: Nasopharynx -- Cancer -- Radiotherapy
Hong Kong Polytechnic University -- Dissertations
Department: Dept. of Optometry and Radiography
Pages: v, 43 leaves : ill. ; 30 cm
Language: English
InnoPac Record: http://library.polyu.edu.hk/record=b1602848
URI: http://theses.lib.polyu.edu.hk/handle/200/2016
Abstract: Nasopharyngeal carcinoma (NPC) is one of the commonest cancers in Hong Kong. Hong Kong has throughout the years earned great fame in effective treatment of this disease. In the Prince of Wales Hospital, Teo et al. (1996 & 2000) found 78.8% of the cases to be free from local recurrence following conventional radiotherapy. In 1997, a stereotactic radiotherapy system was installed in the department. The advantage of stereotactic radiotherapy (SRT) is its precision in the delivery of high radiation dose to the tumor while the surrounding tissue is spared. In so doing, better tumor control might be achieved and this improves the treatment result. Twenty-seven eligible cases have received treatment with this new treatment technique, following conventional treatment, and have been evaluated in this study. The main objective of this study was to explore the initial response of these patients to treatment, as compared to those treated by conventional treatment alone. The overall local control by SRT was 92.6% as compared to 72% by conventional treatment alone. The disease free survival was 66.7% against the conventional survival of 66.2%. The overall survival was, however, poorer, i.e. 77.8% by SRT to 86.3% by conventional treatment. By comparing the sample with the historical cohort of patients published by Teo et al. (1996), it was found that the apparent improvement in local control by SRT was borderline (0.05 < p < 0.1) in significance (p=0.0897). The disease free survival was also marginal (p=0.0792) after SRT and metastatic free survivals were similar (p=0.7522) for the sample cohort. It appeared that even if SRT booster improved local control, the prognosis of the patients was little enhanced. Taking into account the small sample size and short follow-up interval, it was unfair to make any concluding statement on the findings. Meanwhile, it could not be undermined that inadequate local control would lead to local recurrence and distant metastasis later, so any chance that could improve local control should be grasped. On the other hand, the data revealed about = 20% increases in local control for the N0/1 group and =50% for N2 and N3 groups. These were impressive results, suggesting SRT might be beneficial for advanced T-tumors. In so saying, SRT boost might still be tried under a clinical trial setting for the treatment of NPC even though it was not significant statistically for the mean time. For more reliable measurements on the effect of SRT and for more conclusive and elaborative findings, it is suggested to perform a further review about 2 years later on a larger group of patients treated with SRT.

Files in this item

Files Size Format
b1602848x.pdf 2.010Mb PDF
Copyright Undertaking
As a bona fide Library user, I declare that:
  1. I will abide by the rules and legal ordinances governing copyright regarding the use of the Database.
  2. I will use the Database for the purpose of my research or private study only and not for circulation or further reproduction or any other purpose.
  3. I agree to indemnify and hold the University harmless from and against any loss, damage, cost, liability or expenses arising from copyright infringement or unauthorized usage.
By downloading any item(s) listed above, you acknowledge that you have read and understood the copyright undertaking as stated above, and agree to be bound by all of its terms.

     

Quick Search

Browse

More Information