The effectiveness of local application of aqueous cream and amorphous hydrogel on the radiated skin as a measure to prevent skin reactions in patients with nasopharyngeal cancer who are undergoing radiotherapy

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The effectiveness of local application of aqueous cream and amorphous hydrogel on the radiated skin as a measure to prevent skin reactions in patients with nasopharyngeal cancer who are undergoing radiotherapy

 

Author: Yu, Sau-ling
Title: The effectiveness of local application of aqueous cream and amorphous hydrogel on the radiated skin as a measure to prevent skin reactions in patients with nasopharyngeal cancer who are undergoing radiotherapy
Degree: M.Sc.
Year: 2006
Subject: Hong Kong Polytechnic University -- Dissertations
Nasopharynx -- Cancer -- Radiotherapy -- Complications
Skin -- Effect of radiation on
Department: School of Nursing
Pages: iii, 64 leaves : col. ill. ; 30 cm
Language: English
InnoPac Record: http://library.polyu.edu.hk/record=b1893947
URI: http://theses.lib.polyu.edu.hk/handle/200/2096
Abstract: Radiotherapy skin reactions occur commonly in clinical practice and cause number of problems for patients and their carers. Purpose / aim: The purpose of this study was to determine whether the application of aqueous cream and amorphous hydrogel would decrease the incidence of skin reactions including erythema, dry desquamation, and confluent desquamation; toxicity of pain and itchy in patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy. Design: Quasi-experimental clinical trial study. Setting: Radiotherapy centre in a private hospital. Sample: 40 patients with nasopharyngeal carcinoma, who required a full course of radiotherapy using intensity-modulated radiation therapy (IMRT). Intervention: Prophylactic skin care began on the first day of radiotherapy and continue daily (including non-treatment days) until four weeks after the end of treatment. Patients were assigned to the experimental group using aqueous cream with amorphous hydrogel. Patients were instructed to apply aqueous cream and amorphous hydrogel to the area at various intervals throughout the course of treatment. Aqueous cream was used on the first two weeks and the last two weeks. On week three and four, aqueous cream and amorphous hydrogel were used twice a day alternately. From fifth week onwards till the ninth week, only hydrogel was used four times a day. Results: Aqueous cream and hydrogel was significantly better effective in reducing the incidence of skin reaction including erythema (P = 0.00a), dry desquamation (P = 0.003a) and itchy toxicity (P = 0.004a), but they did not significantly reduce confluent desquamation (P = 0.133a) and radiation-induced skin pain (P = 0.93a). (a, Log Rank test) Conclusion: Although the sample size was small, there is a place for cream and hydrogel as a prophylactic skin care in the prevention of radiation-induced skin reactions.

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