Evaluation of cerebrovascular stenosis and associated risk factors in Hong Kong Chinese by MR angiography

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Evaluation of cerebrovascular stenosis and associated risk factors in Hong Kong Chinese by MR angiography


Author: Lee, Raymond
Title: Evaluation of cerebrovascular stenosis and associated risk factors in Hong Kong Chinese by MR angiography
Degree: M.Sc.
Year: 1999
Subject: Cerebrovascular disease -- Risk factors -- China -- Hong Kong
Chinese -- China -- Hong Kong
Angiography -- China -- Hong Kong
Magnetic resonance imaging -- China -- Hong Kong
Hong Kong Polytechnic University -- Dissertations
Department: Multi-disciplinary Studies
Dept. of Optometry and Radiography
Pages: x, 90 leaves : ill. (some col.) ; 30 cm
Language: English
InnoPac Record: http://library.polyu.edu.hk/record=b1479919
URI: http://theses.lib.polyu.edu.hk/handle/200/2333
Abstract: Cerebrovascular stenosis is the major cause of stroke in Chinese. More patients suspected of cerebrovascular stenosis will now be assessed by magnetic resonance angiography (MRA) because of its increased availability, high accuracy and non-invasiveness. The prevalence of cerebrovascular stenosis is not well documented in Hong Kong. Because of the geographical difference in the incidence of cerebrovascular stenosis in Chinese, it is worthwhile to be further elucidated by examining a population in Hong Kong to establish a local data base of incidence of cerebrovascular stenosis for future reference. Moreover, exploring the risk factors associated with stenosis may help to reduce its incidence by modifying those factors. This study had two main aims. The first aim was to evaluate the prevalence of extracranial carotid artery (ECCA) and intracranial cerebral artery (ICCA) stenosis in Hong Kong Chinese by MR angiography. Moreover, this study aimed to explore the correlation of cerebrovascular risk factors with stenosis. Current study is a cross-sectional study which studied MR angiography of 165 intracranial cerebral artery (ICCA) cases and 146 extracranial carotid artery (ECCA) cases obtained from transient ischemic attack (TIA) or ischemic stroke patients. Risk factors were obtained from medical history. MR angiography was done with subsequent image assessment by radiologists. Arteries with highest degree of stenosis were picked up by the radiologists and classified from normal to occlusion. The grading of stenosis was then correlated to their risk factors. Results demonstrated that prevalence of hemodynamically ICCA significant stenosis (>50% narrowing) was 47% whereas hemodynamically ECCA significant stenosis was 17%. Age, systolic blood pressure (SBP), and fasting blood glucose (FBG) were significantly associated with ICCA stenosis whilst age and SBP were significantly associated with ECCA stenosis. There was no statistical significant association of sex, smoking, obesity with stenosis. Results also suggested that treatment of corresponding risk factors by taking anti-hypertensive and anti-diabetic medication may associate with lower incidence of cerebrovascular stenosis. This study concluded that Hong Kong Chinese had higher prevalence of ICCA than ECCA stenosis. Hypertension, diabetes and age were the most important risk factors in cerebrovascular stenosis. Current study provided a baseline study of prevalence of cerebrovascular in Hong Kong Chinese for future reference and studies. It also demonstrated that magnetic resonance angiography (MRA) was a reliable imaging modality for assessing cerebrovascular stenosis.

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