Multidrug resistance detection in leukemia by flow cytometry with MRK16 monoclonal antibody and functional dye efflux

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Multidrug resistance detection in leukemia by flow cytometry with MRK16 monoclonal antibody and functional dye efflux

 

Author: Lam, Cheuk-ming Matthew
Title: Multidrug resistance detection in leukemia by flow cytometry with MRK16 monoclonal antibody and functional dye efflux
Degree: M.Sc.
Year: 2001
Subject: Leukemia -- Chemotherapy
Multidrug resistance
Hong Kong Polytechnic University -- Dissertations
Department: Multi-disciplinary Studies
Dept. of Applied Biology and Chemical Technology
Pages: viii, 69 leaves : ill. ; 30 cm
Language: English
InnoPac Record: http://library.polyu.edu.hk/record=b1577039
URI: http://theses.lib.polyu.edu.hk/handle/200/2539
Abstract: Multidrug Resistance (MDR) is an important factor which hampers the effectiveness of chemotherapy of a wide range of cancers. The overexpression of P-glycoprotein (Pgp) and other related transporter proteins is one of the main cause of resistance, and are well recognised in clinical samples. A proper laboratory diagnosis of clinical multidrug resistance is important for managing appropriate treatment regimens. Using both immunological and functional assays to detect overexpression of Pgp and other multidrug transporters, it was found that 75% and 64% of leukemic blast samples were positive for MDR. The effect of modulator/reversal agent on leukemic blasts drug retention may provide a clue to modify treatment. In addition, nine discordant Pgp+/ Efflux- and Pgp-/ Efflux+ cases were found in this study of 36 leukemic samples.

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