The effect of extracorporeal shock wave therapy (ESWT) on tendinosis in a rat model

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The effect of extracorporeal shock wave therapy (ESWT) on tendinosis in a rat model

 

Author: Phang, Yuen-wang Joy
Title: The effect of extracorporeal shock wave therapy (ESWT) on tendinosis in a rat model
Degree: M.Sc.
Year: 2008
Subject: Hong Kong Polytechnic University -- Dissertations.
Extracorporeal shock wave therapy.
Tendons -- Diseases -- Animal models.
Tendinitis -- Treatment.
Achilles tendon -- Wounds and injuries -- Treatment.
Department: Dept. of Rehabilitation Sciences
Pages: x, 76 leaves : ill. (some col.) ; 30 cm.
Language: English
InnoPac Record: http://library.polyu.edu.hk/record=b2174194
URI: http://theses.lib.polyu.edu.hk/handle/200/2553
Abstract: A tendinosis model of Achilles tendon in ten three-month-old Sprague-Dawley rats was induced by treadmill running with 10o decline and extra 10% of their body weight load. The running regime was 1 hour daily for 28 consecutive days. Extracorporeal shock wave (ESWT) with 0.12mJ/mm2 at the depth of 5mm was applied to the right Achilles tendon on the 21st and 28th days of the running programme. Five rats neither ran nor received ESWT with cage activity served as control group. On the 35th day, the rats were sacrificed and their Achilles tendons were harvested for biomechanical testing of load relaxation properties, stiflhess, and ultimate tensile strength (UTS) and also light microscopy analysis. No significant difference in load to failure [N] (p = 0.152), tendon stiffness [N/mm] (p= 0.055), and per cent load relaxation [%] (p= 0.444) was found between run-ESWT and run-non-ESWT groups at 35th day post running. It was shown that the there was significant difference in percent load-relaxation between the control and the run-ESWT group (p = 0.029); and between the control and run-non-ESWT group (p= 0.019). On histomorphogical analysis, the running group demonstrated high cellularity and collagen bundle disorganization as compared to the non-running group. This may imply loaded eccentric running regime in rats has imposed partial tendon degeneration by overuse injury. The findings of this study revealed that tendinosis has been partially induced in a rat model by decline treadmill running program and that the present protocol of ESWT application on 21st and 28th days has no significant benefit on the ultimate tensile strength, stiflhess and viscoelasticity behaviour of the rats' Achilles tendons, when compared with non-ESWT contra lateral side.

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