A study of the relationship between glycaemic control and selected atherosclerosis risk factors in type 2 diabetes

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A study of the relationship between glycaemic control and selected atherosclerosis risk factors in type 2 diabetes


Author: Shum, Chung-sun Roy
Title: A study of the relationship between glycaemic control and selected atherosclerosis risk factors in type 2 diabetes
Degree: M.Sc.
Year: 2007
Subject: Hong Kong Polytechnic University -- Dissertations.
Non-insulin-dependent diabetes -- Risk factors.
Diabetes -- Treatment.
Department: Dept. of Health Technology and Informatics
Pages: vii, 93 leaves : ill. ; 30 cm.
Language: English
InnoPac Record: http://library.polyu.edu.hk/record=b2198994
URI: http://theses.lib.polyu.edu.hk/handle/200/3130
Abstract: Diabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycaemia. The disorder had presented huge challenges to the world. The prevalence of diabetes for all age groups worldwide was estimated to be 4.4% by 2030, which is 366 million people. In Hong Kong, the all age prevalence rate is about 10% and the rate for the elderly was projected to 27% by the year of 2033. About 90% DM patients are of Type 2. Type 2 DM patients has a number of complications and atherosclerosis is one of the most serious complications that all of the DM patients have to face. The aim of the study was to investigate the relationship between the glycaemic control and the some of the risk factors of atherosclerosis. Altogether 72 patients from the United Christian Hospital DM clinic were recruited. The HBA|C levels and the fasting blood glucose (FBG) levels (glycaemic control indices) of 72 Type 2 DM patients would be compared with Soluble P-selectin (sP-selectin), lipid profile (fasting plasma total cholesterol, high density lipoprotein (HDL) and low density lipoprotein (LDL) and triglycerides), total white blood cell (WBC) count, monocytes count, Platelet count, mean platelet volume (MPV), plateletocrit (Pet), high sensitivity C-reactive protein (hsCRP), Malondialdehyde (MDA) and Allantoin across 'poor' (HBA1c >7.5 % or FBG > 7.4 mmol/1) and 'good' (HBA1c < 7.0 % or FBG < 7.4 mmol/1) glycaemic control groups. Inter-relationships between glycaemic groups and risk factors of atherosclerosis would be investigated. Special focus would be on sP-selectin. The MPV, Pet and sP-selectin were significantly higher in the poor HBAic group and HBA|C correlated significantly with monocyte count, MPV and Pet in group overall. No factors were significantly higher in the poor control group (FBG > 7.4) and also no factors correlated with FBG either in the good (FBG < 7.4) and poor (FBG > 7.4) control groups. WBC, MPV, Pet and MDA correlated with sP-selectin significantly in group overall. The hsCRP, MDA and the allantoin did not show significant differences between poor and good control groups, and also not correlate with either HBA1c or FBG value in group overall. HBA1c is a more appropriate glycaemic control marker than the snapshot FBG value with respect to the risk factors studied and the findings also supported that the better the glycaemic control the lesser the risk of developing atherosclerosis as MPV, Pet and sP-selectin showed a conspicuous difference between the good and poor control group when grouped according to the HBA!c value and correlated better in the poor control groups in this study. Also sP-selectin exhibited a linear positive relationship with WBC Count, MPV, Pet, MDA and hsCRP, indicating their concerted effort and the interdependent nature in the course of atherosclerosis development.

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