The comparison of survival time of patients using two different transarterial chemoembolization treatment protocol for inoperable hepatocellular carcinoma

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The comparison of survival time of patients using two different transarterial chemoembolization treatment protocol for inoperable hepatocellular carcinoma

 

Author: Chan, King-kwong
Title: The comparison of survival time of patients using two different transarterial chemoembolization treatment protocol for inoperable hepatocellular carcinoma
Degree: M.Sc.
Year: 2001
Subject: Liver -- Cancer -- Treatment
Hong Kong Polytechnic University -- Dissertations
Department: Multi-disciplinary Studies
Dept. of Optometry and Radiography
Pages: v, 76, 9 leaves : ill. (some col.) ; 30 cm
Language: English
InnoPac Record: http://library.polyu.edu.hk/record=b1573338
URI: http://theses.lib.polyu.edu.hk/handle/200/3257
Abstract: Hepatocellular carcinoma is a common malignant disease in Hong Kong. Owing to the fast growing and silent nature, most of the hepatocellular carcinomas become inoperable. Transarterial chemoembolization (TACE) treatment is considered as an effective treatment for patients who are not eligible to be candidates for hepatic surgery. The effect of TACE on patient survival is still controversial in various studies. Recently, early diagnosis of an active lesion and repeated TACE procedures was identified as an effective improvement for the survival time in inoperable hepatocellular carcinoma patients. However the effect of the treatment schedule on the survival time has seldom been considered. The major aim of the present study was to compare the survival time of patients with inoperable hepatocellular carcinoma using the new treatment protocol with that of the traditional methodology in a local center. The potential prognostic factors which affect the survival time of such patients were also investigated. In the present study, 40 inoperable hepatocellular carcinoma patients with conventional transarterial chemoembolization treatment protocol and 38 inoperable hepatocellular carcinoma patients with new TACE treatment protocol were included. The time interval between two TACE sessions in the conventional and the new protocols were 6 and 8 weeks respectively. The conventional protocol had regular subsequent plain computed tomography (CT) examinations with the supplement of elective contrast CT, while the new protocol bad regular alternative plain and contrast CT follow-up examinations after each TACE session. The results showed that the new TACE treatment leads to a significant improvement in survival time as compared with the conventional one. In addition, the study showed the new transarterial chemoembolization treatment was effective in the improvement of survival time of patients with Okuda Stage 1, Pugh-Child Class A, main tumour diameter smaller than 10 cm, nodular and niultinodular tumour, an absence of metastasis and absence of portal vein invasion. The prognostic factors associated with survival time in TACE treatment were treatment protocol, Okuda Stage, tumour type, presence of metastasis and presence of portal vein invasion.

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