Simulation of brainstem auditory evoked potentials

Pao Yue-kong Library Electronic Theses Database

Simulation of brainstem auditory evoked potentials

 

Author: Cheung, Chi-hung Alex
Title: Simulation of brainstem auditory evoked potentials
Degree: M.Sc.
Year: 1998
Subject: Auditory evoked response -- Computer simulation
Auditory evoked response -- Mathematical models
Evoked potentials (Electrophysiology)
Auditory pathways
Hong Kong Polytechnic University -- Dissertations
Department: Multi-disciplinary Studies
Pages: 88 leaves : ill. ; 29 cm
Language: English
InnoPac Record: http://library.polyu.edu.hk/record=b1439094
URI: http://theses.lib.polyu.edu.hk/handle/200/3304
Abstract: Volume conductor computation has been used intensively for solving bio-electric problems in nerve and muscle fiber study Recently the concept of Propagation Point Source Response (PPSR) is introduced which provide an analytical separation of the conducting nerve fiber characteristics from the bio-electric source. With this concept, the transfer function of a particular nerve system become the impulse response of it. This dissertation extend this approach into the human head model and simulate the auditory evoked potentials by computing the PPSR of the auditory pathway. First the human head is modelled as a sphere specified by equivalent radius and conductivity. The deviation from such model and the necessary adjustments are discussed. A coordinate system is also defined based on the traditional anatomical data. Nuclei along the auditory pathway will first be identified and located on the coordinate system. Then, by joining some of these nuclei with straight lines, the auditory pathway is approximated. Afterwards, the field equation of bio-electric properties of the auditory pathway in the human head model will be solved using spherical coordinates. From these analytical solution, the propagating point source response of the auditory pathway can be computed by 2D Fourier Transform technique. The defined auditory pathway are divided into 14 paths and the PPSR of each segment is computed individually. To form the overall response, these 14 paths are interconnected at the end-points (nucleus) after determination of synaptic delay of the nuclei, relative proportions of nerve fiber tracts and the possible asychronous firing time at nuclei. The factors affecting the accuracy of the human head model and the auditory pathway will be discussed Also, the computation efficiency and the resolution requirements for the mathematical calculation will be investigated as well. At last, a simple application of the simulated response is demostrated.

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