A preliminary study of the association between Apolipoprotein E2 allele and type 2 diabetes mellitus and its renal complications in Chinese subjects

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A preliminary study of the association between Apolipoprotein E2 allele and type 2 diabetes mellitus and its renal complications in Chinese subjects

 

Author: Law, Wai-yin
Title: A preliminary study of the association between Apolipoprotein E2 allele and type 2 diabetes mellitus and its renal complications in Chinese subjects
Degree: M.Sc.
Year: 2007
Subject: Hong Kong Polytechnic University -- Dissertations.
Apolipoprotein E.
Diabetes -- Genetic aspects.
Kidneys -- Diseases.
Department: Dept. of Health Technology and Informatics
Pages: viii, 80 leaves : ill. (some col.) ; 30 cm.
Language: English
InnoPac Record: http://library.polyu.edu.hk/record=b2198992
URI: http://theses.lib.polyu.edu.hk/handle/200/3390
Abstract: In Hong Kong, the incidence of end-stage renal disease has now reached 267 patients per million of population. The most common cause of end stage renal disease is diabetic nephropathy (DN). This complication is associated with 2 to 4-fold increase in the incidence of cardiovascular disease and premature death. In DN patients, triglyceride (TG) levels in plasma are elevated. Numerous studies have implicated Apolipoprotein E (APOE), a polymorphic gene with three common alleles (s2, z3, e4), to be associated with diabetic nephropathy because of its effect on lipid metabolism. Nevertheless, there are conflicting reports in different ethnic populations. The present study was undertaken to investigate whether there is an association between the APOE s2 allele and type 2 diabetes mellitus as well as its renal complications in Chinese subjects. This is a cross-sectional study carried out at a local diabetic clinic. In the study, 155 diabetic patients were taken as the subjects. The Apolipoprotein E polymorphism, urinary albumin-creatinine ratio and biochemical parameters (such as serum creatinine, total cholesterol, triglycerides, HDL cholesterol, fasting blood glucose, haemoglobin Ale, malondialdehyde, ascorbic acid), blood pressure, body mass index (BMI) and waist-hip-ratio (WHR) were evaluated. Among these 155 patients with type 2 diabetic mellitus, the allele frequency (s2/e3/s4, 8.1%/82.6%/9.3%) was similar to a local non-diabetic population. Urinary albumin was present in 30.4% of 138 diabetic subjects and the incidence was not associated with APOE e2 allele. There was also no association seen between renal function expressed as the Modification of Diet in Renal Disease (MDRD) predicted glomerular filtration rate (GFR) and APOE e2 allele among 152 diabetic subjects. There were significant differences in ascorbic acid, waist-to-hip ratio, hypertension and dyslipidaemia in nephropathy and without nephropathy group. These data do not suggest an association of the Apolipoprotein E gene with type 2 diabetes and its renal complications but control of obesity and hypertension should decrease the risk of nephropathy in Chinese type 2 diabetic patients.

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