Effects of ultrasound coupling with panax notoginseng gel on ligament healing in a rat model

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Effects of ultrasound coupling with panax notoginseng gel on ligament healing in a rat model


Author: Wong, Yuk-fai Richard
Title: Effects of ultrasound coupling with panax notoginseng gel on ligament healing in a rat model
Degree: M.Sc.
Year: 2007
Subject: Hong Kong Polytechnic University -- Dissertations.
Ultrasonics in medicine.
Soft tissue injuries -- Treatment.
Rats as laboratory animals.
Department: Dept. of Rehabilitation Sciences
Pages: xiii, 65 leaves : ill. (some col.) ; 30 cm.
Language: English
OneSearch: https://www.lib.polyu.edu.hk/bib/b2276493
URI: http://theses.lib.polyu.edu.hk/handle/200/4393
Abstract: The purpose of this study was to evaluate the effects of therapeutic ultrasound coupled with Panax notoginseng (PNS) gel on the biomechanical properties of healing medial collateral ligament (MCL) of knee in rats. Twenty Sprague-Dawley rats with surgically transected MCL of knee were studied. At day 2 after injury, the rats were divided into 3 groups. Seven (Ultrasound group) were treated daily with 1 MHz pulsed (1:1) ultrasound at 0.5 W/cm2, direct contact method using standard therapeutic ultrasound coupling gel for 5 minutes. Seven (PNS group) were treated with the same ultrasound parameters but using PNS gel instead of standard coupling gel. Six (control group) were treated by sham ultrasound with standard coupling gel only. All animals were sacrificed on day 17 and their MCLs of both legs were tested for viscoelastic load-relaxation, structural stiffness and ultimate tensile strength (UTS). The data analysis was performed with one way analysis of variance with the level of significance set at 0.05. The results showed that the stiffness of PNS group was significantly higher than ultrasound (P=0.023) and control (P=0.003). The UTS of PNS group was also significantly higher than ultrasound (P=0.036) and control (P=0.009) group. Although the mean stiffness and UTS of ultrasound group were higher than those of control group, there was no statistically significant difference. The viscoelastic load-relaxation of all groups showed no significant difference. The findings of this study showed that ultrasound coupled with PNS gel was beneficial for the healing process of transected MCL of knee in rats in the early stage of injury (2 weeks post-injury). Further studies on testing PNS effect on different stages of healing and parameters of ultrasound and animals are essential to support the clinical use of this new method of treatment for soft tissues injuries. The present study provided preliminary evidence for a new treatment modality that combined physiotherapy and herbs in the management of soft tissue injury and a foundation for further research in the area of herbal medicine on connective tissue injury.

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