Effects of low-voltage microamperage stimulation on tendon healing in rats

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Effects of low-voltage microamperage stimulation on tendon healing in rats


Author: Chan, Kwai-fong Helen
Title: Effects of low-voltage microamperage stimulation on tendon healing in rats
Degree: M.Sc.
Year: 2005
Subject: Hong Kong Polytechnic University -- Dissertations
Tendons -- Wounds and injuries -- Treatment
Department: Dept. of Rehabilitation Sciences
Pages: x, 89 leaves : ill. (some col.) ; 30 cm
Language: English
InnoPac Record: http://library.polyu.edu.hk/record=b1818221
URI: http://theses.lib.polyu.edu.hk/handle/200/4488
Abstract: Fourteen 3-month old male Sprague-Dawley rats received surgical transection to the medial band of their right Achilles tendons (TAs) and they were randomly divided into the low-voltage microamperage stimulation (LVMAS) group (n=7) and control group (n=7). Starting on post-operative day 6, the LVMAS group received transcutaneous LVMAS treatment (2.5 V, 100 uA/ cm2, 10 Hz, anodal electrode on injury site), while the control group received placebo LVMAS with the power unit turned off. Each treatment lasted for 30 minutes with 6 sessions per week for 4 weeks. At post-injury day 31, all the rats were sacrificed and the TAs were harvested for biomechanical testing of load-relaxation, stiffness and ultimate tensile strength (UTS). Each parameter was normalized against the respective value of the left TA of the same animal and then analyzed between groups with independent t-test of 帢 at 0.05. The results showed that UTS of the LVMAS group was significantly higher than the control group (p=0.014). Trends of better performance in stiffness and load-relaxation were also demonstrated in the LVMAS group than the control group but these differences were not significant (p=0.239 and 0.350 respectively). The present study suggested that transcutaneous application of LVMAS could improve the biomechanical strength of partially ruptured TAs of rats at 1 month after injury.

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