A study of Id-1, Bcl-2 and EGFR in breast cancer patients and the relationship to prognosis and treatment outcome

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A study of Id-1, Bcl-2 and EGFR in breast cancer patients and the relationship to prognosis and treatment outcome

 

Author: Tsang, Chong-chi Michael
Title: A study of Id-1, Bcl-2 and EGFR in breast cancer patients and the relationship to prognosis and treatment outcome
Degree: M.Sc.
Year: 2009
Subject: Hong Kong Polytechnic University -- Dissertations.
Breast -- Cancer -- Research -- China -- Hong Kong.
Breast -- Cancer -- Patients -- China -- Hong Kong.
Epidermal growth factor -- Receptors.
Department: Dept. of Health Technology and Informatics
Pages: xiii, 102 leaves : ill. (chiefly col.) ; 30 cm.
Language: English
InnoPac Record: http://library.polyu.edu.hk/record=b2305597
URI: http://theses.lib.polyu.edu.hk/handle/200/4897
Abstract: Breast cancer is the most common form of cancer among women. The most common post-operative treatment methods are adjuvant therapy and hormonal therapy. ER and PR are current markers for oncologists to determine post-operative endocrine treatment strategies. However, low grade breast cancer with borderline endocrine responsiveness may develop into hormonal refractory disease. Inhibitor of cell differentiation (Id-1) is believed to have a role in the progression of breast cancer from hormone-dependent to hormonal independent stage. Bcl-2 regulates the cell survival and its presence predicts more favourable outcome in breast cancers. Epidermal growth factor receptors (EGFR) play critical roles in multiple cellular processes and are found in various types of human cancer. The present study aimed to analyse the correlations of Id-1 with Bcl-2, EGFR expression and ER in hormonal and chemotherapy treated breast cancer patients using immunohistochemical technique. Inverse correlation between Id-1 expression and ER status was found in the study (r=-0.472, P<0.001). Breast cancer tumor grade inversely correlated with Bcl-2 expression but not correlated with Id-1 expression. Inverse correlation between Id-1 and Bcl-2 expression (r=-0.257, P=0.011) was found and was believed to be related to hormonal sensitivity of breast epithelial cells. Positive correlation between Id-1 and EGFR expression was observed (r=0.336, P=0.001) and both proteins were related to breast cancer progression, especially in low grade tumor (P=0.018). For analyzing suitability of endocrine therapy, positive correlation between Id-1 and EGFR expression in hormonal sensitive cancer group (P=0.048) and negative correlation between Id-1 and Bcl-2 expression in hormonal insensitive cancer group (P=0.034) were found; however, no relationship between treatment methods and survival was found and these findings might not be helpful for choosing endocrine therapy or chemotherapy at the moment. Id-1 expression and ER status being prognostic factor was found in the cases and prognostic influence of Id-1 associated with steroid receptor status was suggested. This study further supported that inhibition of Id-1 might be beneficial for breast tumors and leading to the future therapeutic strategies.

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