Comparison between the velocities of micro-particles inside PDMS & PEG chips

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Comparison between the velocities of micro-particles inside PDMS & PEG chips


Author: Leung, Wing-hang Rick
Title: Comparison between the velocities of micro-particles inside PDMS & PEG chips
Degree: M.Sc.
Year: 2010
Subject: Hong Kong Polytechnic University -- Dissertations
Microelectromechanical systems
Microfluidic devices
Polyethylene glycol
Department: Dept. of Health Technology and Informatics
Pages: viii, 84 leaves : ill. (some col.) ; 30 cm.
InnoPac Record:
Abstract: Polydimethylsiloxane (PDMS) has long been suggested to be a suitable material for manufacturing micro-fluidic chip. However, there are still disadvantages for PDMS when manufacturing microchip with specific purpose. Researchers have been keeping searching for new materials for microchip fabrication in order to replace PDMS. Therefore, new material like Polyethylene glycol (PEG) has already been studied to explore the possibility to be the platform for microchips. In this experiment, both PDMS and PEG microchips has been manufactured with micro-channels inside both microchips. Fluorescence micro-particles (20nm) were injected into the micro-channels in both the PDMS and PEG microchips. Then an electronic pump with five designated speed was used to create pressure for the micro-particles' movement inside both microchips. A high-speed camera was used to capture the movements of the micro-particles inside the micro-channels of both chips. From the results, it shown that the micro-particles moved faster inside the PEG than the PDMS chip. In addition, PEG has shown a better performance from measuring the water contact angle and the result from the protein absorption experiments. In summary, it suggested that molecules were moving faster inside the PEG micro-fluidic chip than the PDMS micro-fluidic chip. Thus PEG may have an advantage in manufacturing micro-fluidic device aimed for bio-senor or bio-molecules testing platform.

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