Effect of gallic acid and ursolic acid on glioma cell migration and invasion

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Effect of gallic acid and ursolic acid on glioma cell migration and invasion


Author: Cheng, Ka-man, Karman
Title: Effect of gallic acid and ursolic acid on glioma cell migration and invasion
Degree: M.Sc.
Year: 2010
Subject: Hong Kong Polytechnic University -- Dissertations
Glioblastoma multiforme -- Treatment.
Gallic acid
Carboxylic acids
Department: Dept. of Health Technology and Informatics
Pages: xi, 88 leaves : ill. (some col.) ; 31 cm.
InnoPac Record: http://library.polyu.edu.hk/record=b2352718
URI: http://theses.lib.polyu.edu.hk/handle/200/5630
Abstract: Glioblastoma multiforme is an aggressive and invasive primary brain tumor due to its migration and invasion abilities. Deregulation of kinases and enzymes, phosphoinositide-3-kinase (PI3K) p110δ isoform, protein kinase B (Akt), focal adhesion kinase (FAK), matrix metalloproteinase-2 (MMP-2) and MMP-9, occur commonly in gliomagenesis resulting in tumor migration, invasion and metastasis. Chinese gall and Prunella vulgaris are two traditional Chinese medicinal herbs that have been used in treating cancers for thousands ofyears. In this study, two active components, gallic acid and ursolic acid, extracted from Chinese gall and Prunella vulgaris respectively, were examined to determine if they could inhibit glioma cell viability, migration and invasion. Both drugs were effective in killing glioma cells in a dose-dependent manner. However, gallic acid was more effective in suppressing glioma migration and invasion than ursolic acid. It significantly inhibited glioma cell migration in an in vitro migration assay and suppressed the expression of PI3K p110δ, pAkt and FAK in Western blot analysis. Reduction of MMP-2 and MMP-9 expression and activity were showed by gelatin zymography. Downregulation of these proteases might contribute to the decreased glioma cell invasiveness. These results suggest that treatment targeting PI3K p110δ, pAkt, FAK, MMP-2 and MMP-9 could be useful for inhibiting glioma migration and invasion. Gallic acid could be a possible chemotherapeutic agent for glioblastoma multiforme.

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