Effects of aerobic exercise training on exercise capacity, cardiac function and quality of life in chronic heart failure patients with cardiac resynchronization therapy : a pilot study

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Effects of aerobic exercise training on exercise capacity, cardiac function and quality of life in chronic heart failure patients with cardiac resynchronization therapy : a pilot study

 

Author: Yunk, Ka-lung Bernard
Title: Effects of aerobic exercise training on exercise capacity, cardiac function and quality of life in chronic heart failure patients with cardiac resynchronization therapy : a pilot study
Degree: M.Sc.
Year: 2010
Subject: Hong Kong Polytechnic University -- Dissertations
Aerobic exercises -- Physiological aspects
Heart failure -- Exercise therapy.
Cardiac pacemakers
Department: Dept. of Rehabilitation Sciences
Pages: xii, 98 leaves : ill. ; 30 cm.
InnoPac Record: http://library.polyu.edu.hk/record=b2353070
URI: http://theses.lib.polyu.edu.hk/handle/200/5658
Abstract: Background: The objective of this study was to investigate the exercise capacity, cardiac function and quality of life in patients with chronic heart failure prior to implantation of cardiac resynchronization therapy (CRT), after 1 month of implantation and after an 8-week exercise training programme. Methods and results: Seven chronic heart failure patients (5 men and 2 female) with CRT implantation were randomized to either the aerobic exercise training (AET) group or a control group. The AET group performed 8-week exercise training program and the control group remained physically inactive. Results: Four subjects (two of them being heart transplant candidates) were allocated to the AET group and 3 patients were allocated to the control group. Two subjects in AET group were withdrawn due to heart transplantation and repeated gouty attacks on lower limbs. After 1 month of CRT implantation, the peak oxygen consumption (peak VO₂), 6-minutes walk test distance (6MWT) and quality of life score (MLHFQ) for all subjects were similar to baseline but left ventricular ejection fraction (LVEF) has improved from 29.5±6.6 to 36.0±7.2 percent. After 8 week of AET, the two remaining subjects in the AET group showed an increase in peak VO₂(AET: 26.5% ,control: 11.8%), peak heart rate (HR) (AET: 15.1 % , control: 3.6%), decrease in left ventricular end diastolic diameter (LVEDd) (AET: -2%, control: 0.9%), left ventricular end systolic diameter (LVESd) (AET: -7% control: 0%), mitral regurgitation (MR) score (AET: -100%, control: 28%). 1 female subject in AET group was successfully removed in heart transplantation list during exercise phase. Conclusion: Aerobic exercise training is safe and feasible for chronic heart failure patients with cardiac resynchronization therapy. More subjects are required to show the improvement on 6MWT distance, MLHFQ score and other parameters of cardiac function such as MR, LVEDd and LVESd.

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