Expression of toll-like receptors 1-9, CK7, CK19 and glypican3 in liver neoplasms

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Expression of toll-like receptors 1-9, CK7, CK19 and glypican3 in liver neoplasms


Author: Ng, Man-hay
Title: Expression of toll-like receptors 1-9, CK7, CK19 and glypican3 in liver neoplasms
Degree: M.Sc.
Year: 2010
Subject: Hong Kong Polytechnic University -- Dissertations
Liver -- Cancer
Liver metastasis
Cell receptors -- Diagnostic use
Department: Dept. of Health Technology and Informatics
Pages: vii, 104 leaves : col. ill. ; 31 cm.
InnoPac Record:
Abstract: Toll like receptors (TLRs) have been showed in various types of tissues which mediate innate and adaptive immune response against particular types of pathogen-associated molecular patterns (PAMPs) from micro-organisms. TLRs are involved in many human diseases and cancers. In the 1iver, TLRs had been shown in hepatitis infection, cirrhosis and alcoholic liver diseases etc. In cancer, previous findings suggested the dual role of TLRs-tumor-promoting or anti-tumor. In this experiment, expression of TLRs1-9 in nonnal and malignant livers was investigated by immunohistochemistry. We observed that nonnal liver had the highest frequencies of TLRs1-9 expression among non-neoplastic livers, cirrhotic livers and malignant livers. However, no significant differences in frequencies of TLRs expression were observed between non-neoplastic and cancers; non-neoplastic and cirrhotic livers; and cirrhotic livers and cancers. Moreover, hepatitis B infection status and the presence of oncofeta1 protein glypican3 showed no significant difference of TLRs expression in hepatocellular caccinoma. The decreased frequencies of TLRs expression in liver cancer indicated the failure of TLRs-mediated immune response against tumor cells and might contribute to hepatocarcinogenesis, thus highlighted the potential anti-tumor effect of TLRs in liver tumors.

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