Clinicopathological characteristics of basal-like subtype invasive ductal carcinoma identified with immunohistochemical expression of ER, PR, HER2, CK5/6 and EGFR

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Clinicopathological characteristics of basal-like subtype invasive ductal carcinoma identified with immunohistochemical expression of ER, PR, HER2, CK5/6 and EGFR

 

Author: Yung, Kwai-ying
Title: Clinicopathological characteristics of basal-like subtype invasive ductal carcinoma identified with immunohistochemical expression of ER, PR, HER2, CK5/6 and EGFR
Degree: M.Sc.
Year: 2010
Subject: Hong Kong Polytechnic University -- Dissertations
Breast -- Cancer -- Molecular aspects.
Diagnostic immunohistochemistry
Cancer invasiveness
Department: Dept. of Health Technology and Informatics
Pages: xv, 90, [41] leaves : ill. (some col.) ; 31 cm.
Language: English
InnoPac Record: http://library.polyu.edu.hk/record=b2355954
URI: http://theses.lib.polyu.edu.hk/handle/200/5819
Abstract: Background: In the past decade, breast cancer was proposed to be classified into five molecular subtypes: luminal A & B, HER2, basal-like and normal breast like. These different subtypes have distinct gene expression profile demonstrated by DNA microarray. Studies in the West shown that the basal-like subtype was mostly associated with higher grade, larger tumor size and poorer prognosis. Whereas, studies on the association of clinicopathological features of the basal-like subtype have not been done in the Hong Kong Chinese population. Here, the prevalence and clinicopathological characteristics of the basal-like subtype IDC, NOS in the Hong Kong Chinese population was investigated. Methods: A retrospective study using a panel of five immunohistochemical markers (ER, PR, HER2, CK5/6 & EGFR) was employed to identify the basal-like subtype among 1016 cases of invasive ductal carcinoma, their clinicopathological characteristics as well as some distinct morphological features were also evaluated. Results: The percentage of IDC, NOS with triple negative phenotype was found to be about 14.7% and the percentage of basal-like subtype tumors which were either CK5/6 and/or EGFR positive identified within the subgroup with triple negative phenotype was 46.3%. Both the triple-negative and basal-like carcinoma were found to have larger tumor size, higher grade but with less nodal involvement. They were also found to be associated with the presence of hyaline fibrotic scar, geographic necrosis and lymphocytic infiltrate. Conclusion: The percentage of tumor with triple negative phenotype (14.7%) in the Hong Kong Chinese population was found to be similar to its prevalence in other Asian countries. The triple negative and basal-like breast carcinoma were found to be associated with poorer prognostic indicators, such as larger tumor size and higher tumor grade. The use of CK5/6 and EGFR can be used as the tools for identifying basal-like breast cancer and directing the therapeutic strategy for its treatment.

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