Investigation of the effects of green tea consumption on cardiovascular risk biomarkers in type 2 diabetic patients

Pao Yue-kong Library Electronic Theses Database

Investigation of the effects of green tea consumption on cardiovascular risk biomarkers in type 2 diabetic patients

 

Author: Chiu, Chun Sze
Title: Investigation of the effects of green tea consumption on cardiovascular risk biomarkers in type 2 diabetic patients
Degree: M.Sc.
Year: 2012
Subject: Diabetes -- Treatment.
Green tea -- Therapeutic use.
Cardiovascular system -- Diseases -- Treatment.
Hong Kong Polytechnic University -- Dissertations
Department: Dept. of Health Technology and Informatics
Pages: xiii, 154 leaves : ill. (some col.) ; 30 cm.
Language: English
InnoPac Record: http://library.polyu.edu.hk/record=b2520212
URI: http://theses.lib.polyu.edu.hk/handle/200/6556
Abstract: Introduction: Type 2 diabetic mellitus is a common metabolic disorder worldwide and cardiovascular disease accounts for high morbidity and mortality in diabetic population. Elevated oxidative stress due to increased generation of reactive oxygen species and compromised endogenous antioxidant defense in diabetics is associated with accelerated atherosclerosis, an underlying cause of cardiovascular disease. Under circumstances of increased oxidative stress, lipids will be modified. Together with endothelial dysfunction caused by uncoupling of nitric oxide synthesis and advanced glycation end products induced inflammation, atherosclerosis is initiated and accelerated. Green tea which possesses high content of catechins and antioxidant capacity is suggested to be cardioprotective via effects like lowering oxidative stress and blood pressure, improving endothelial function, hypolipidaemic and anti-inflammatory effects. It is worthwhile to investigate the effects of green tea consumption on cardiovascular risk biomarkers in type 2 diabetic patients who are at high cardiovascular risk in this single blinded, randomized, crossover, intervention study. Objectives: In this investigation, the effects of green tea consumption on cardiovascular risk biomarkers in type 2 diabetic patients were studied. It also aimed at studying the relationship between cardiovascular risk biomarkers.
Methods: 56 type 2 diabetic patients of both genders aged from 32 to 80 years old (59.6 ± 9.8 years old) were recruited. Each participant was randomized to receive two different 12-weeks interventions with a washout period of 12 weeks in between. They were required to consume 2 cups of 250 ml hot water or 2 cups of 250 ml of 1% w/v green tea daily during each intervention period. Overnight fasting venous blood sample were collected at the beginning and at the end of each intervention period. Plasma was obtained for measurement. Triglycerides, total cholesterol, high density lipoprotein cholesterol (HDL cholesterol) and low density lipoprotein cholesterol (LDL cholesterol) were assessed as the lipid profile. High sensitivity C reactive protein (hsCRP) and vascular cell adhesion molecule -1 (VCAM-1) were utilized as inflammatory and endothelial function biomarkers, respectively. Asymmetric dimethylarginine (ADMA) and uric acid were also measured. Commercial test kits were utilized for the measurement of lipid profile, hsCRP and uric acid. VCAM-1 was determined by commercially available enzyme linked immunosorbent assay (ELISA) kit and ADMA was detected by high performance liquid chromatography (HPLC) following solid phase extraction. Results: No significant difference was detected between green tea and water intervention with respect to lipid profile, hsCRP, ADMA and uric acid. VCAM-1 was significantly reduced in female (p<0.05). Correlation analysis showed positive relationships between total cholesterol and HDL cholesterol, total cholesterol and LDL cholesterol and triglycerides and uric acid. Inverse associations were found between triglycerides and HDL cholesterol and between uric acid and HDL cholesterol. Conclusion: In conclusion, 12 weeks of green tea consumption exerts no significant effect on improving lipid profile, hsCRP, ADMA and uric acid. Nonetheless, green tea can improve the endothelial function by decreasing VCAM-1 level. Lowering of triglycerides may be particularly important for diabetic population to reduce cardiovascular risks as it is related to various cardiovascular risk biomarkers.

Files in this item

Files Size Format
b25202121.pdf 2.468Mb PDF
Copyright Undertaking
As a bona fide Library user, I declare that:
  1. I will abide by the rules and legal ordinances governing copyright regarding the use of the Database.
  2. I will use the Database for the purpose of my research or private study only and not for circulation or further reproduction or any other purpose.
  3. I agree to indemnify and hold the University harmless from and against any loss, damage, cost, liability or expenses arising from copyright infringement or unauthorized usage.
By downloading any item(s) listed above, you acknowledge that you have read and understood the copyright undertaking as stated above, and agree to be bound by all of its terms.

     

Quick Search

Browse

More Information