Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor | Department of Health Technology and Informatics | en_US |
| dc.creator | Chiu, Chun Sze | - |
| dc.identifier.uri | https://theses.lib.polyu.edu.hk/handle/200/6556 | - |
| dc.language | English | en_US |
| dc.publisher | Hong Kong Polytechnic University | - |
| dc.rights | All rights reserved | en_US |
| dc.title | Investigation of the effects of green tea consumption on cardiovascular risk biomarkers in type 2 diabetic patients | en_US |
| dcterms.abstract | Introduction: Type 2 diabetic mellitus is a common metabolic disorder worldwide and cardiovascular disease accounts for high morbidity and mortality in diabetic population. Elevated oxidative stress due to increased generation of reactive oxygen species and compromised endogenous antioxidant defense in diabetics is associated with accelerated atherosclerosis, an underlying cause of cardiovascular disease. Under circumstances of increased oxidative stress, lipids will be modified. Together with endothelial dysfunction caused by uncoupling of nitric oxide synthesis and advanced glycation end products induced inflammation, atherosclerosis is initiated and accelerated. Green tea which possesses high content of catechins and antioxidant capacity is suggested to be cardioprotective via effects like lowering oxidative stress and blood pressure, improving endothelial function, hypolipidaemic and anti-inflammatory effects. It is worthwhile to investigate the effects of green tea consumption on cardiovascular risk biomarkers in type 2 diabetic patients who are at high cardiovascular risk in this single blinded, randomized, crossover, intervention study. Objectives: In this investigation, the effects of green tea consumption on cardiovascular risk biomarkers in type 2 diabetic patients were studied. It also aimed at studying the relationship between cardiovascular risk biomarkers. | en_US |
| dcterms.abstract | Methods: 56 type 2 diabetic patients of both genders aged from 32 to 80 years old (59.6 ± 9.8 years old) were recruited. Each participant was randomized to receive two different 12-weeks interventions with a washout period of 12 weeks in between. They were required to consume 2 cups of 250 ml hot water or 2 cups of 250 ml of 1% w/v green tea daily during each intervention period. Overnight fasting venous blood sample were collected at the beginning and at the end of each intervention period. Plasma was obtained for measurement. Triglycerides, total cholesterol, high density lipoprotein cholesterol (HDL cholesterol) and low density lipoprotein cholesterol (LDL cholesterol) were assessed as the lipid profile. High sensitivity C reactive protein (hsCRP) and vascular cell adhesion molecule -1 (VCAM-1) were utilized as inflammatory and endothelial function biomarkers, respectively. Asymmetric dimethylarginine (ADMA) and uric acid were also measured. Commercial test kits were utilized for the measurement of lipid profile, hsCRP and uric acid. VCAM-1 was determined by commercially available enzyme linked immunosorbent assay (ELISA) kit and ADMA was detected by high performance liquid chromatography (HPLC) following solid phase extraction. Results: No significant difference was detected between green tea and water intervention with respect to lipid profile, hsCRP, ADMA and uric acid. VCAM-1 was significantly reduced in female (p<0.05). Correlation analysis showed positive relationships between total cholesterol and HDL cholesterol, total cholesterol and LDL cholesterol and triglycerides and uric acid. Inverse associations were found between triglycerides and HDL cholesterol and between uric acid and HDL cholesterol. Conclusion: In conclusion, 12 weeks of green tea consumption exerts no significant effect on improving lipid profile, hsCRP, ADMA and uric acid. Nonetheless, green tea can improve the endothelial function by decreasing VCAM-1 level. Lowering of triglycerides may be particularly important for diabetic population to reduce cardiovascular risks as it is related to various cardiovascular risk biomarkers. | en_US |
| dcterms.extent | xiii, 154 leaves : ill. (some col.) ; 30 cm. | en_US |
| dcterms.isPartOf | PolyU Electronic Theses | en_US |
| dcterms.issued | 2012 | en_US |
| dcterms.educationalLevel | All Master | en_US |
| dcterms.educationalLevel | M.Sc. | en_US |
| dcterms.LCSH | Diabetes -- Treatment. | en_US |
| dcterms.LCSH | Green tea -- Therapeutic use. | en_US |
| dcterms.LCSH | Cardiovascular system -- Diseases -- Treatment. | en_US |
| dcterms.LCSH | Hong Kong Polytechnic University -- Dissertations | en_US |
| dcterms.accessRights | restricted access | en_US |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| b25202121.pdf | For All Users (off-campus access for PolyU Staff & Students only) | 2.41 MB | Adobe PDF | View/Open |
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