Effect of green tea supplementation on plasma and urine polyphenol concentrations in type 2 diabetes subjects : results of a controlled intervention study

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Effect of green tea supplementation on plasma and urine polyphenol concentrations in type 2 diabetes subjects : results of a controlled intervention study

 

Author: Tsang, Kwan Yi
Title: Effect of green tea supplementation on plasma and urine polyphenol concentrations in type 2 diabetes subjects : results of a controlled intervention study
Degree: M.Sc.
Year: 2012
Subject: Green tea -- Therapeutic use.
Non-insulin-dependent diabetes -- Treatment.
Hong Kong Polytechnic University -- Dissertations
Department: Dept. of Health Technology and Informatics
Pages: xvii, 135 leaves : ill. ; 30 cm.
Language: English
InnoPac Record: http://library.polyu.edu.hk/record=b2523629
URI: http://theses.lib.polyu.edu.hk/handle/200/6630
Abstract: Many studies have shown that antioxidant-rich green tea has a wide variety of beneficial effects in relation to risk of many diseases associated with increased oxidative stress, such as Type 2 diabetes. In this study, 41 Type 2 diabetes subjects were recruited with their informed consent for a placebo-controlled intervention trial with green tea. The subjects were divided into two groups randomly, the experimental treatment was 2 cups (150ml/cup of 1.5% w/v tea) of green tea daily for 12 weeks and the placebo treatment was the same volume of hot water. After 12 weeks washout period, the two groups were crossed over onto the treatment for a second supplementation period of 12 weeks. The concentration of free and total catechins (EGCG, ECG, EGC, EC and C) in plasma and urine were analysed by LC-MS/MS to assess the tea-related changes. Results showed significant (P<0.05) increases after tea supplementation in the concentration of free (unconjugated) EGCG , total (unconjugated+conjugated) EGCG ECG and EGC in plasma with the mean±SD levels of 0.140±0.505, 0.228±0.376, 0.192±0.338 and 0.080±0.253 uM respectively. In addition, free (unconjugated) EGC and total (unconjugated+conjugated) EGC, EC and EGCG in urine were increased (P<0.05) with the mean±SD levels of 75.54 ±323.80, 602.4±1644.0, 109.5±331.5 and 7.98±36.47 nmol/mmol creatinine respectively. Results indicate drinking 2 cups of green tea daily as supplementation might maintain a relatively high concentration of free EGCG in plasma, and give a greater beneficial function to the Type 2 diabetes subjects comparing with placebo treatment, but this needs to be further investigation by looking at the biomarkers of oxidative stress that might be modulated by EGCG.

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