Evaluation of the relationship between metabolic syndrome and a novel profile of high sensitivity C-reactive protein, alanine aminotransferase, gamma-glutamyl transferase and interleukin-18, with probable relation to aging

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Evaluation of the relationship between metabolic syndrome and a novel profile of high sensitivity C-reactive protein, alanine aminotransferase, gamma-glutamyl transferase and interleukin-18, with probable relation to aging

 

Author: Yuen, Tat-kwong Henry
Title: Evaluation of the relationship between metabolic syndrome and a novel profile of high sensitivity C-reactive protein, alanine aminotransferase, gamma-glutamyl transferase and interleukin-18, with probable relation to aging
Degree: M.Sc.
Year: 2012
Subject: Metabolic syndrome.
Biochemical markers -- Diagnostic use.
Hong Kong Polytechnic University -- Dissertations
Department: Dept. of Health Technology and Informatics
Pages: vii, 84 leaves : ill. ; 30 cm.
Language: English
InnoPac Record: http://library.polyu.edu.hk/record=b2523631
URI: http://theses.lib.polyu.edu.hk/handle/200/6632
Abstract: Metabolic Syndrome (MetS) is a group of interrelated risk factors including hyperglycaemia, insulin resistance, dyslipidema and hypertension. Patients of MetS are at increased risk for development of type 2 diabetes mellitus (DM) and cardiovascular diseases (CVD). Some studies proposed that some biomarkers are related to increased risk of MetS. But only hsCRP has been considered with important clinical value in identifying an individual with increased risk of atherosclerotic disease with metabolic disorder. As GGT, ALT and IL-18 are involved in some areas of pathogenesis for MetS, it is reasonable to believe that they are related to MetS. This study aims at evaluating the potential biomarkers GGT, ALT and IL-18. Through studying the relation between these biomarkers and MetS, their potential usefulness in indicating the status of MetS was investigated. A cross-sectional study was carried out with 151 subjects diagnosed with MetS using the Adult Treatment Penal III (ATP III) criteria. The data of age, gender and components of MetS were obtained from a large project studying the MetS and yoga exercise. The blood level of GGT, ALT, IL-18 and hsCRP were measured and the association between the biomarkers and components of MetS was investigated, with comparison to hsCRP. Moreover, the potential relation between those biomarkers and age of subjects was analysed. The levels of GGT, ALT, IL-18 and hsCRP were generally increased for the MetS subjects. A significant correlation between GGT and three of the MetS components was observed. ALT (r = -0.21, p = 0.01) and IL-18 (r = -0.29, p = 0.01) were correlated negatively with HDL. GGT activity was found significantly correlated with hsCRP, (r = 0.196, p = 0.02). With linear regression analysis, GGT level was found varied due to the change of systolic blood pressure, triglyceride and waist circumference. On the other hand, no trend of variation was found in GGT, ALT, IL-18 and hsCRP with respect to different age group in the female subjects, with a mean age of 54.3 years. Therefore, GGT may be a sensitive biomarker for MetS and is helpful in screening MetS case with adversely affected liver function. Those biomarkers studied may not vary due to age change in older women. Large-scale studies with subjects of wider range of age are needed for further justification of the GGT, ALT and IL-18 as biomarkers for MetS.

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