Assessment of matrix metalloproteinase-9 activity in metabolic syndrome

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Assessment of matrix metalloproteinase-9 activity in metabolic syndrome

 

Author: Chan, Shui Yi
Title: Assessment of matrix metalloproteinase-9 activity in metabolic syndrome
Degree: M.Sc.
Year: 2013
Subject: Metabolic syndrome.
Metalloproteinases.
Extracellular matrix proteins.
Hong Kong Polytechnic University -- Dissertations
Department: Dept. of Health Technology and Informatics
Pages: viii, 77 leaves : ill. ; 30 cm.
Language: English
InnoPac Record: http://library.polyu.edu.hk/record=b2637099
URI: http://theses.lib.polyu.edu.hk/handle/200/7114
Abstract: The prevalence of the metabolic syndrome is increasing worldwide. The syndrome is associated with the cardiovascular risk with an increased morbidity and mortality. A pathophysiological mechanism responsible for the increased risk has not been elucidated. Abnormal MMP-9 activity, which contributes to pathological vascular remodeling, may be one of the components linking the metabolic syndrome to the development of cardiovascular disease. In this project, the alteration of MMP-9 activity on patient with metabolic syndrome and their association with metabolic syndrome component were studied. In our study, no significant difference of total level of free MMP-9 level was found between subjects with and without metabolic syndrome. No correction was found among the total level of free MMP-9 and the components of the metabolic components including the level of glucose, triglyceride, blood pressure, HDL and waist circumference, but significant difference of total level of free MMP-9 was found between the aged group and the young group of the subject. In conclusion, no difference on the total level of free MMP-9 was shown in metabolic syndrome patient compared with healthy subjects. The increased total level of free MMP-9 found in aged group might suggest a possibly relevant pathophysiological mechanism that involved in the increase of cardiovascular risk associated with aging.

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