Serum endothelin-1 level and its association with elevated blood pressure in Hong Kong Chinese adults with metabolic syndrome

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Serum endothelin-1 level and its association with elevated blood pressure in Hong Kong Chinese adults with metabolic syndrome


Author: Yau, Yin Fan Wendy
Title: Serum endothelin-1 level and its association with elevated blood pressure in Hong Kong Chinese adults with metabolic syndrome
Degree: M.Sc.
Year: 2013
Subject: Metabolic syndrome.
Hong Kong Polytechnic University -- Dissertations
Department: Dept. of Health Technology and Informatics
Pages: xi, 90 leaves : ill. ; 30 cm.
Language: English
Abstract: Metabolic syndrome (MetS) was collectively defined as a clustering of metabolic abnormalities including elevated blood pressure, hyperglycaemia, dyslipidaemia, and abdominal obesity. MetS was positively associated with the risk of developing type 2 diabetes mellitus and cardiovascular diseases as well as increased mortality for all-cause. The prevalence of MetS in a group of apparently healthy population was becoming alarmingly high in all developed countries worldwide. Elevated blood pressure was always the highest prevalent component in MetS and hypertension was also the leading global risk accounting for 13% of deaths that strongly associated with cardiovascular diseases causing nearly 30% of mortality. Though the mechanism involved in the development of high blood pressure in MetS has not been fully resolved, the deleterious effect of metabolic abnormalities in MetS on the vascular endothelium leading to endothelial dysfunction attributed by the impairments of endogenous vasodilation primarily mediated by nitric oxide (NO) and vasoconstriction mediated by endothelin-1 (ET-1) was highly suspected. ET-1 was one of the potent endogenous vasoconstrictive peptides elicited strong vascular smooth muscle cell-dependent vasoconstriction as well as cell proliferation and differentiation but weak endothelium-dependent vasodilation that might favour the development and maintenance of high blood pressure in MetS. Objective: To determine the serum ET-1 levels in the subjects with and without MetS defined by the NCEP ATP III criteria and its association with high blood pressure in MetS in the middle-age and older (50 - 64 years) of the Hong Kong Chinese.
Methodology: Thirty-six frozen serum samples were retrieved each from the defined MetS and without MetS group. Serum samples were archived from Chinese subjects recruited by a local community-wide MetS screening campaign, who had no evidence or a history of severe or acute cardiovascular diseases, heart disorder, stroke, diagnosed diabetes mellitus or on drugs due to diseases. Assay for ET-1: Serum ET-1 was assayed from the retrieved frozen serum samples by chemiluminescent enzyme-linked immunoassay kit. Results: Serum ET-1 levels were significantly elevated in the subjects with MetS compared to subjects without MetS (1.46 ± 0.11 verses 1.15 ± 0.07 pg/ mL, P = 0.020); with greater waist circumference (1.43 ± 0.61 verses 1.13 ± 0.45 pg/ mL, P = 0.026) and impaired fasting glucose (1.51 ± 0.69 verses 1.19 ± 0.46 pg/ mL, P = 0.037). Serum ET-1 levels were correlated to the increasing number of MetS components with a significant trend (rs = 0.263, P = 0.026). Statistically significant interaction effect of systolic blood pressure and age on serum ET-1 concentration (P = 0.048) was also demonstrated. Conclusion: Elevated ET-1 levels expression may play a role in the pathogenesis of MetS and elevated blood pressure interacted with age. Further studies in larger scale with administration of pharmacological ET receptor antagonists were suggested to investigate the potential role of ET-1 as a pharmacological target in age-specific strategies focused on prevention and treatment of high blood pressure in MetS.

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