Validation of gene expression of ITGA7 and ITGB3 induced by p110δ in the pathogenesis of glioblastoma multiforme

Pao Yue-kong Library Electronic Theses Database

Validation of gene expression of ITGA7 and ITGB3 induced by p110δ in the pathogenesis of glioblastoma multiforme

 

Author: Cheung, Hoi Yan, Jade
Title: Validation of gene expression of ITGA7 and ITGB3 induced by p110δ in the pathogenesis of glioblastoma multiforme
Degree: M.Sc.
Year: 2013
Subject: Glioblastoma multiforme.
Gliomas -- Genetic aspects.
Hong Kong Polytechnic University -- Dissertations
Department: Dept. of Health Technology and Informatics
Pages: xii, 93 leaves : ill. ; 30 cm.
Language: English
InnoPac Record: http://library.polyu.edu.hk/record=b2637101
URI: http://theses.lib.polyu.edu.hk/handle/200/7199
Abstract: Glioblastoma (GBM) is a common brain cancer with poor prognosis. The average survival time of patients is around one year and it is not much improved over a few decades. Several pathways such as Rho/ROCK, PTEN/PI3K, and MAPK) have been showed that is related in molecular adhesion and cell signaling. PI3K isoforms p110δ was found to play an important role in cell migration and invasion. Gene expression profile found that integrin are correlated to the cell migration and invasion. It functions not only as receptors to recognize ligands, but takes part in the adhesion process. More evidences proved that integrins have over expression or suppression in GBM. Based on the study screening of functional roles of p110δ with associated the gene expression levels of adhesion molecules, significant up-regulated and down-regulated genes are Integrin α7(ITGA7) and Integrin β3(ITGB3) respectively. Validations are performed to consolidate the findings and therefore can move forwards of these genetic works. Integration of the ongoing research with previous study can provide further evidence of significant gene expression of ITGA7 and ITGB3 in U87-MG with p110δ knocking down.

Files in this item

Files Size Format
b26371017.pdf 2.429Mb PDF
Copyright Undertaking
As a bona fide Library user, I declare that:
  1. I will abide by the rules and legal ordinances governing copyright regarding the use of the Database.
  2. I will use the Database for the purpose of my research or private study only and not for circulation or further reproduction or any other purpose.
  3. I agree to indemnify and hold the University harmless from and against any loss, damage, cost, liability or expenses arising from copyright infringement or unauthorized usage.
By downloading any item(s) listed above, you acknowledge that you have read and understood the copyright undertaking as stated above, and agree to be bound by all of its terms.

     

Quick Search

Browse

More Information