Synthesis of novel photoactive degradable polymers with potential in biomedical applications

Pao Yue-kong Library Electronic Theses Database

Synthesis of novel photoactive degradable polymers with potential in biomedical applications


Author: Guo, Bing
Title: Synthesis of novel photoactive degradable polymers with potential in biomedical applications
Degree: M.Phil.
Year: 2014
Subject: Polymers -- Biodegradation.
Polymers -- Synthesis.
Polymeric composites.
Hong Kong Polytechnic University -- Dissertations
Department: Institute of Textiles and Clothing
Pages: xxx, 220 leaves : illustrations ; 30 cm
Language: English
Abstract: Synthetic biopolymers have received considerable attention in recent years in view of their tremendous potential in the fields of medicine and tissue engineering applications. Star-shaped biopolymers containing multi arms radiating from a core center represent an appealing candidate as drug carrier for drug delivery application. In this study, a range of novel photoactive star-shaped and linear biodegradable polymers are synthesized by ring-opening and condensation polymerization techniques respectively. The star-shaped polymers were prepared using porphyrin, lactide, caprolactone, and glycolide as building blocks. The synthesized polymers generally varied in terms of not only composition and but also molecular weight controlled by the feed ratios of the monomers to initiator in their reactions. A comprehensive study is conducted to determine the effect of reaction parameters to the properties of the polymers, based on a range of analytical techniques such as FTIR, NMR, GPC, UV-Vis, fluorescence, WAXRD, DSC, TG, and DMA. Besides, extensive work is carried out to evaluate their performance in various potential applications such as drug delivery and shape memory. For the drug delivery study, a few of the star-shaped polymers are chosen and fabricated with anti-cancer drugs via an emulsion and solvent evaporation technique. The resulting drug loaded nanoparticles are investigated in terms of drug loading efficiency, drug release profile as well as other useful physical and chemical properties. For the shape memory study, novel linear and star-shaped polymers are prepared in different molecular compositions. The shape memory effect of the films obtained from solvent casting is studied by means of DSC, XRD, DMA and shape memory measurements over cyclic mechanical tests. The sample polymers are also subjected to a cytotoxicity assay in order to gain an insight about their biocompatibility.

Files in this item

Files Size Format
b27575160.pdf 8.894Mb PDF
Copyright Undertaking
As a bona fide Library user, I declare that:
  1. I will abide by the rules and legal ordinances governing copyright regarding the use of the Database.
  2. I will use the Database for the purpose of my research or private study only and not for circulation or further reproduction or any other purpose.
  3. I agree to indemnify and hold the University harmless from and against any loss, damage, cost, liability or expenses arising from copyright infringement or unauthorized usage.
By downloading any item(s) listed above, you acknowledge that you have read and understood the copyright undertaking as stated above, and agree to be bound by all of its terms.


Quick Search


More Information