Graphene quantum dots : magnetic nanoparticle composite based cellular drug delivery carrier system

Pao Yue-kong Library Electronic Theses Database

Graphene quantum dots : magnetic nanoparticle composite based cellular drug delivery carrier system

 

Author: Teng, Yun
Title: Graphene quantum dots : magnetic nanoparticle composite based cellular drug delivery carrier system
Degree: M.Sc.
Year: 2014
Subject: Quantum dots.
Graphene.
Nanomedicine.
Hong Kong Polytechnic University -- Dissertations
Department: Interdisciplinary Division of Biomedical Engineering
Pages: xv, 76 leaves : color illustrations. ; 30 cm
Language: English
InnoPac Record: http://library.polyu.edu.hk/record=b2757741
URI: http://theses.lib.polyu.edu.hk/handle/200/7556
Abstract: Recently, the functionalized graphene quantum dots has more attention because of their multifunctional properties concern, just like high surface area, low toxicity and good stability. Graphene quantum dots can in some cases be used as nano-drug itself. Therefore, it is considered to be a great potential for drug delivery applications, diagnosis, treatment, and sensing, in particular controlled, because they are installed and to maintain potency of the drug release rate of the drug delivery system over the fixedly. While functionalized graphene nano systems can produce an unbelievable promotion in nano medicine filed. Not only to carry the drug, drug delivery and controlling the drug efficiency in the drug delivery process. the tracking and evaluation of visualization. As for magnetic nanoparticals, research on magnetic nanoparticles has been a very active area of research people, because there are many important applications. for example: drug delivery, imaging and hyperthermia. Hyperthermia has been used for many years for the treatment of cancer and various patients. which that at 42 ~ 45°C. the tumor cells are necrotic, charring or coagulation. In addition. the cells are more sensitive than the normal at this temperature range. In this experiment, we synthesis of GQD and MNP through EDC/NHS reaction, and we calculated the quality GQD on GQD-MNP composite. We conclude that the FA-GQD-MNP can get into cell faster to produce stronger blue fluorescence through the imaging of cellular uptake and the fluorescence intensity of comparison among GQD, GQD-MNP and FA-GQD-MNP. In addition, we try to demonstrate the influence of adding local concentration for cellular uptake. We demonstrate that adding local concentration can promote the cellular uptake of FA-GQD-MNP composites through the magnetic attraction experiment. Through the cytotoxicity assessment. we conclude that FA-GQD-MNP composite has lower cytotoxicity than pure GQD and GQD-MNP; it indicates that FA-GQD-MNP has the potential to carry drugs for selectively killing cancer cells in vitro.

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