Longitudinal characterization and interpretation of functional parameters during zebrafish heart regeneration

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Longitudinal characterization and interpretation of functional parameters during zebrafish heart regeneration

 

Author: Yu, Sihang
Title: Longitudinal characterization and interpretation of functional parameters during zebrafish heart regeneration
Degree: M.Sc.
Year: 2014
Subject: Heart function tests
Heart -- Research
Hong Kong Polytechnic University -- Dissertations
Department: Interdisciplinary Division of Biomedical Engineering
Pages: vii, 40 leaves : illustrations ; 30 cm
Language: English
InnoPac Record: http://library.polyu.edu.hk/record=b2757744
URI: http://theses.lib.polyu.edu.hk/handle/200/7558
Abstract: In this project, we propose a characterization model that provides a comprehensive depiction as well as interpretation of cardiac contractility during the regeneration process of zebrafish. The 20% ventricle amputated zebrafish will serve as an experimental model for studying how the cardiac functions are regained after myocardial infarction. The Doppler spectrogram is first generated using Matlab based on traditional Pulse wave Doppler signal processing techniques. Doppler mode indices such as E/A ratio and deceleration time (DT) are then examined longitudinally. We were able to verify from a functional level that the increased E/A velocity ratio, which often reflects impaired ventricle relaxation, can also be found during zebrafish regeneration process. As the heart gradually replaces the scar tissue with newly differentiated myocardium, the ventricle regains its compliance and realizes its functional recovery. The E/A ratio gradually returns to the initial value. In addition, smoothing techniques were preforming on the Doppler signal in the hope that errors caused factors such as measurement angles may be reduced and the measurements on the Doppler spectrogram can be therefore improved.

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