Phosphate clearance kinetics : a comparison of hemophan and polysulfone in hemodialysis

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Phosphate clearance kinetics : a comparison of hemophan and polysulfone in hemodialysis


Author: Lo, Ming-yuen Kevin
Title: Phosphate clearance kinetics : a comparison of hemophan and polysulfone in hemodialysis
Year: 2000
Subject: Hemodialysis
Kidneys -- Diseases -- Treatment
Hong Kong Polytechnic University -- Dissertations
Department: Multi-disciplinary Studies
Jockey Club Rehabilitation Engineering Centre
Pages: vi, 70 leaves : ill. (some col.) ; 30 cm
Language: English
InnoPac Record:
Abstract: Urea clearance modeling had been extensively researched by many researchers in the past 20 years. However, the urea molecule is electrically neutral and such a model cannot be applied to the clearance of charged molecules/radicals in the blood, such as phosphate. The author established a phosphate clearance model, which is similar to the urea model but including an additional electrodynamic factor inside the model. Phosphate clearance was studied using such a model as well as experimentally in this research. Two membranes, namely hemophan and polysulfone, were studied and compared. Hemophan was selected because it possesses charged centres on the surface of the membrane (di-ethyl-amino-ethyl group), while polysulfone does not. For comparison, 4 in-vitro experiments were done using bovine blood in normal hemodialysis (HD) on both membranes under the same conditions. Cloning is also an important issue need to handle during in-vitro tests; hence heparin was used as anti-coagulant. Continuous add-in of heparin is more beneficial than a bolus dose in order to avoid system clotting of dialyser. Clotting function affecting on clearance of dialyser is also suggested for further studies. Results suggested that hemophan offers a better clearance in phosphate compared with polysulfone. In contrast, for the clearance of urea, polysulfone is better than hemophan accordingly. These experimental results also compared with theoretical results derived from the phosphate and urea models. Reasonably comparable results were obtained. Results also indicated that, clearance of both urea and phosphate is more effective in the first 2 hours. A shorter but more frequent hemodialysis is suggested in order to maximize the effects of clearance of wastes from renal failure patients.

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