| Author: | Au, Ka Ching Kent |
| Title: | The effect of habitual exercise-induced Sirt-3 on mitochondrial adaptation in skeletal muscle of rat |
| Advisors: | Siu, Parco (HTI) |
| Degree: | M.Sc. |
| Year: | 2015 |
| Subject: | Mitochondrial pathology. Musculoskeletal system. Rats -- Physiology Hong Kong Polytechnic University -- Dissertations |
| Department: | Department of Health Technology and Informatics |
| Pages: | xiii, 97 leaves : illustrations ; 30 cm |
| Language: | English |
| Abstract: | Mitochondrial Sirtuin-3 (Sirt-3) is a member of the class III histone deacetylases, which possess nicotinamide adenine dinucleotide (NAD+) dependent deactylase and adenosine diphosphate (ADP) ribosyltransferase activities. In the last decade, Sirt-3 has become a highly promising target for curing mitochondrial disorders. This current study examined the effect of long term habitual exercise on the expression of Sirt-3 in plantaris muscle and its correlation with mitochondrial content indicated by the level of Cytochrome c oxidase subunit-4 (Cox-4) protein. 20-week habitual exercise significantly increased the Sirt-3 expression (P < 0.05) and positively correlated with Cox-4 expression in plantaris muscle (P < 0.05). It indicated that Sirt-3 contributed to mitochondrial biogenesis after long term voluntary exercise. It was surprising to demonstrate that Sirt-3 was significantly correlated with the transformation of muscle fibre form type-IIb/IIx to IIa (P < 0.05). Collectively, prolonged habitual exercise induced Sirt-3 could possibly promote both mitochondrial biogenesis and fibre type transformation. |
| Rights: | All rights reserved |
| Access: | restricted access |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| b28013633.pdf | For All Users (off-campus access for PolyU Staff & Students only) | 5.09 MB | Adobe PDF | View/Open |
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