The effect of habitual exercise-induced Sirt-3 on mitochondrial adaptation in skeletal muscle of rat

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The effect of habitual exercise-induced Sirt-3 on mitochondrial adaptation in skeletal muscle of rat

 

Author: Au, Ka Ching Kent
Title: The effect of habitual exercise-induced Sirt-3 on mitochondrial adaptation in skeletal muscle of rat
Degree: M.Sc.
Year: 2015
Subject: Mitochondrial pathology.
Musculoskeletal system.
Rats -- Physiology
Hong Kong Polytechnic University -- Dissertations
Department: Dept. of Health Technology and Informatics
Pages: xiii, 97 leaves : illustrations ; 30 cm
Language: English
InnoPac Record: http://library.polyu.edu.hk/record=b2801363
URI: http://theses.lib.polyu.edu.hk/handle/200/7908
Abstract: Mitochondrial Sirtuin-3 (Sirt-3) is a member of the class III histone deacetylases, which possess nicotinamide adenine dinucleotide (NAD+) dependent deactylase and adenosine diphosphate (ADP) ribosyltransferase activities. In the last decade, Sirt-3 has become a highly promising target for curing mitochondrial disorders. This current study examined the effect of long term habitual exercise on the expression of Sirt-3 in plantaris muscle and its correlation with mitochondrial content indicated by the level of Cytochrome c oxidase subunit-4 (Cox-4) protein. 20-week habitual exercise significantly increased the Sirt-3 expression (P < 0.05) and positively correlated with Cox-4 expression in plantaris muscle (P < 0.05). It indicated that Sirt-3 contributed to mitochondrial biogenesis after long term voluntary exercise. It was surprising to demonstrate that Sirt-3 was significantly correlated with the transformation of muscle fibre form type-IIb/IIx to IIa (P < 0.05). Collectively, prolonged habitual exercise induced Sirt-3 could possibly promote both mitochondrial biogenesis and fibre type transformation.

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