Magnetic and fluorescent Fe₃O₄@SiO₂-GQDs-FA nanoparticles for simultaneous dual modal imaging and targeted drug delivery

Pao Yue-kong Library Electronic Theses Database

Magnetic and fluorescent Fe₃O₄@SiO₂-GQDs-FA nanoparticles for simultaneous dual modal imaging and targeted drug delivery

 

Author: Su, Xiaoqian
Title: Magnetic and fluorescent Fe₃O₄@SiO₂-GQDs-FA nanoparticles for simultaneous dual modal imaging and targeted drug delivery
Degree: M.Sc.
Year: 2015
Subject: Drug delivery systems.
Nanomedicine.
Hong Kong Polytechnic University -- Dissertations
Department: Interdisciplinary Division of Biomedical Engineering
Pages: xii, 54 pages : color illustrations
Language: English
InnoPac Record: http://library.polyu.edu.hk/record=b2839198
URI: http://theses.lib.polyu.edu.hk/handle/200/8421
Abstract: The development of nanocarriers with multiple functionalities, e.g. multimodal imaging, medical targeting, diagnostics, and therapeutic actions in one material, has attracted considerable interests for biomedical applications. The use of multifunctional nanocarriers for early diagnosis and therapy of diseases is expected to provide significant improvements to the diagnostic accuracy, therapeutic efficiency and minimize side effects. A novel graphene quantum dots (GQDs) based drug delivery system was developed for dual-model imaging and cancer therapy. Magnetic and fluorescent Fe₃O₄@SiO₂-GQDs-FA nanocarriers were successfully fabricated. Specifically, Fe₃O₄ nanoparticles (NPs) were synthesized via a modified co-precipitation method. Core-shell Fe₃O₄@SiO₂ NPs were fabricated by modifying the Stober method via the hydrolysis of tetraethyl orthosilicate (TEOS). The conjugation of GQDs onto the surfaces of amino functionalized Fe₃O₄@SiO₂ NPs was achieved via the classic carbodiimide crosslinker chemistry. The non-covalent π-π stacking was used to load DOX onto the nanocarriers. Luminescent GQDs allows real-time tracing intracellular uptake, suggesting the localization of internalized nanocarriers. The cytotoxicity data suggest that drug-free nanocarriers are highly biocompatible and DOX-loaded nanocarriers are more effective than free DOX in cancer therapy. As mentioned above, these luminomagnetic nanocarriers with excellent biocompatibility, super fluorescence property and good magnetic response would have potential application in diagnosis and therapy. It is revealed that MNPs@SiO₂-GQD-FA nanocarrier is a promising platform for simultaneous dual modal imaging and targeted drug delivery.

Files in this item

Files Size Format
b28391986.pdf 19.48Mb PDF
Copyright Undertaking
As a bona fide Library user, I declare that:
  1. I will abide by the rules and legal ordinances governing copyright regarding the use of the Database.
  2. I will use the Database for the purpose of my research or private study only and not for circulation or further reproduction or any other purpose.
  3. I agree to indemnify and hold the University harmless from and against any loss, damage, cost, liability or expenses arising from copyright infringement or unauthorized usage.
By downloading any item(s) listed above, you acknowledge that you have read and understood the copyright undertaking as stated above, and agree to be bound by all of its terms.

     

Quick Search

Browse

More Information