To investigate the association of matrix metalloproteinase-9 with metabolic syndrome in elderly

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To investigate the association of matrix metalloproteinase-9 with metabolic syndrome in elderly

 

Author: Yu, Sau Shun
Title: To investigate the association of matrix metalloproteinase-9 with metabolic syndrome in elderly
Degree: M.Sc.
Year: 2016
Subject: Metabolic syndrome.
Metalloproteinases
Older people.
Hong Kong Polytechnic University -- Dissertations
Department: Dept. of Health Technology and Informatics
Pages: x, 67 pages : illustrations
Language: English
InnoPac Record: http://library.polyu.edu.hk/record=b2864140
URI: http://theses.lib.polyu.edu.hk/handle/200/8432
Abstract: Metabolic syndrome (MetS) is a worldwide health problem, especially in elderly. In fact, MetS is closely related to cardiovascular diseases (CVDs) and diabetes (Newby, 2005). Matrix metalloproteinase-9 (MMP-9) is associated with CVDs, it is because abnormal level of MMP-9 would remodel the endothelial basal membrane, that promote erosion and thrombosis (Raffetto, et al., 2008). The extracellular matrix proteins, mainly the type IV collagen would be degraded by the MMP-9 (Balkau, et al., 2007). For this reason, the objective of this project is to investigate the association of matrix metalloproteinase-9 with metabolic syndrome in elderly (aged over 60 years). In this study, serum MMP-9 levels were significantly different between subjects in MetS compared with the subjects in non-MetS group (P<0.05). All 5 MetS components including blood pressure, waist circumference, triglycerides, HDL-cholesterol and fasting blood glucose showed significant association with serum MMP-9 levels (P-<0.05). Systolic Blood Pressure (SBP) had the highest correlation coefficient (r=0.669) among other components. The effect of MMP-9 concentration showed significant difference with the number of MetS components (P<0.05). To conclude, the increasing of MMP-9 levels was mainly associated with high blood pressure in the elderly with MetS. Clinically, it was important to study the implications of MMP-9 in cardiovascular risk of MetS subjects. More studies should be carried on the prevention and management of MetS, especially in elderly.

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