Ghrelin in obesity and metabolic syndrome

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Ghrelin in obesity and metabolic syndrome


Author: Ma, Ho Man
Title: Ghrelin in obesity and metabolic syndrome
Degree: M.Sc.
Year: 2016
Subject: Ghrelin.
Metabolic syndrome.
Hong Kong Polytechnic University -- Dissertations
Department: Dept. of Health Technology and Informatics
Pages: 165 pages : illustrations (some color)
Language: English
Abstract: The global epidemic obesity is becoming a major problem of the population in different parts of the world. It leads to chronic diseases such as dyslipidemia, decreasing insulin sensitivity, type 2 diabetes and cardiovascular diseases. For these reasons, they have led to an increased interest in hormonal signal regulation of body weight.Ghrelin is a gut derived hormone synthesised in the stomach. The presence of ghrelin is essential for activation of ghrelin receptor and growth hormone secretagogue receptor. It has been shown to play a central role in modulating the energy homeostasis by stimulating appetite and food intake. It has been postulated that ghrelin could be one of the pathogenesis to weight gain and obesity due to energy intake imbalance. Metabolic syndrome is characterised by a clustering of metabolic disturbances which leads to coronary heart disease and mortality. It is featured by central obesity, dyslipidemia with elevated triglyceride and decreased HDL,hypertension, impaired glucose tolerance and insulin resistance. These may consequently lead to type 2 diabetes and cardiovascular disease and particularly in overweight and obese individuals. Therefore, this study is to study the association of gherlin in obese individuals in developing metabolic syndrome.This study was carried out on 146 subjects valid data on MetS and/or obesity status. The National Cholesterol Education Program-Third Adult Treatment Panel recommended diagnostic criteria was used and define metabolic syndrome and its components. Subjects were divided into 4 groups, obese metabolic syndrome group, metabolic group, obese group and non obese non metabolic syndrome control group. Waist circumference, systolic blood pressure,diastolic blood pressure, triglycerides,high-density lipoprotein and glucose were measured. Plasma acylated and desacylated ghrelin were detected by enzyme-linked immunosorbent assay.
The results of this study suggests that metabolic syndrome is positively associated with body size, blood pressure and blood glucose levels. As regard to triglycerides and high-density lipoprotein, there was a positive association of triglycerides and a negative association of high-density lipoprotein with metabolic syndrome. There is hormonal changes with lower acylated ghrelin, in particularly desacylated ghrelin in association with obesity and metabolic syndrome The great reduction in desacylated ghrelin and increases in acylated/desacylated ghrelin ratio may be involved in the pathophysiology of obesity and metabolic syndrome. And, the decrease of acylated and desacylated ghrelin levels is associated with the numbers of metabolic abormalities, which suggests that plasma ghrelin levels could possibly reflect the chance in developing metabolic syndrome.In conclusion, the present study supports the hypothesis that AG and DAG concnetrations are lower in individuals with MetS compared to obese and normal subjects. And AG and DAG concentraion are lower in individuals with obesity than normal individuals. In particular, the drop in DAG levels, the findings may have clinical relevence as regards the interest of monitoring and identifying the chance of developing obesity and MetS. And together with AG/DAG ratio would probably allows a more accurate idenitification.

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