Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor | Department of Rehabilitation Sciences | en_US |
| dc.contributor.advisor | Ngai, Shirley (RS) | en_US |
| dc.contributor.advisor | Pang, Marco (RS) | en_US |
| dc.creator | He, Wanjia | - |
| dc.identifier.uri | https://theses.lib.polyu.edu.hk/handle/200/11554 | - |
| dc.language | English | en_US |
| dc.publisher | Hong Kong Polytechnic University | en_US |
| dc.rights | All rights reserved | en_US |
| dc.title | Effects of whole-body vibration (WBV) on muscle derangement in cigarette smoke induced chronic obstructive pulmonary disease (COPD)-like model | en_US |
| dcterms.abstract | This thesis aims at examining the effects and exploring the optimal protocol for whole-body vibration (WBV) on muscle derangement in a cigarette smoke-induced chronic obstructive pulmonary disease (COPD)-like model. The literature suggests that cigarette smoke (CS) could induce muscle fiber transformation from I to II, such as in the soleus. It also led to muscle atrophy as reflected by a reduction in the cross-sectional area (CSA) of the hindlimb muscles, such as the soleus. However, an optimal duration of exposure to CS for developing a COPD-like model needed further exploration. It was found that WBV with 20Hz or 30Hz could normalize muscle derangement, i.e. an increase of the CSA in soleus fiber types and the attenuation of soleus muscle fiber transformation from I to II in a model of muscle disuse. Thus, WBV may normalize the muscle derangement in a COPD-like model, but an optimal frequency was still needed to be examined It was shown that exposure to CS for 56 days would significantly increase alveolar airspace, which mimics the emphysematous changes in people with COPD, and derangement in muscle fibers, i.e. muscle fiber transformation from I to II and reduction of CSA in the soleus muscle. These changes were associated with the levels of inflammatory cytokines measured in serum extracted from the soleus muscle as well as oxidative stress in the soleus muscle. Therefore, a 56-day CS exposure model was chosen for the main study. | en_US |
| dcterms.abstract | The main study focused on the examination of the effect of WBV and the exploration of the optimal frequency of WBV on muscle derangement throughout 56 days in a CS exposure-induced COPD-like model. The main study showed that a frequency between 10Hz and 40Hz could cause the inflammatory response. i.e. an increase of IL-1β in serum or TNF-α in the soleus, when compared to the control group. Those inflammatory cytokines may amplify the inflammatory response in people with COPD. However, when the frequency was increased to 50Hz, the percentage and CSA of myosin heavy chain (MHC) types in the CS group were not showing significant difference when compared to the sham-air group (SA) group and the lung function , the pro-inflammatory cytokines in serum and the soleus muscle, oxidative stress were reversed in the COPD-like model. The results suggest that WBV with a frequency of 50Hz for six weeks had beneficial whole-body effects, including normalizing muscle derangement, improving lung function, ameliorating inflammatory response in the soleus and in serum levels in a COPD-like model induced by CS. We speculated that a six-week intervention of WBV with 50Hz (a=0.3g, 15min/day, 6 days/week) would attenuate muscle weakness and fatigue, improve lung function, ameliorate the inflammation reaction in the local and peripheral system, and attenuate the oxidative stress in the limb muscles. Therefore, the WBV intervention could have benefits in both lung and limb muscles. | en_US |
| dcterms.extent | xxv, 302 pages : color illustrations | en_US |
| dcterms.isPartOf | PolyU Electronic Theses | en_US |
| dcterms.issued | 2021 | en_US |
| dcterms.educationalLevel | Ph.D. | en_US |
| dcterms.educationalLevel | All Doctorate | en_US |
| dcterms.LCSH | Vibration -- Therapeutic use | en_US |
| dcterms.LCSH | Lungs -- Diseases, Obstructive -- Treatment | en_US |
| dcterms.LCSH | Hong Kong Polytechnic University -- Dissertations | en_US |
| dcterms.accessRights | open access | en_US |
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