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DC FieldValueLanguage
dc.contributorFaculty of Health and Social Sciencesen_US
dc.contributor.advisorCai, Jing (HTI)en_US
dc.contributor.advisorWu, W. C. Vincent (HTI)en_US
dc.creatorKu, Ki Man-
dc.identifier.urihttps://theses.lib.polyu.edu.hk/handle/200/12249-
dc.languageEnglishen_US
dc.publisherHong Kong Polytechnic Universityen_US
dc.rightsAll rights reserveden_US
dc.titleClinical evaluation of fiducial marker pre-planning for virtual bronchoscopic navigation implantation in lung tumour patients treated with cyberknifeen_US
dcterms.abstractPurpose: For the treatment of invisible lung tumours with CyberKnife (CK), fiducial markers (FMs) were implanted as an internal surrogate under Virtual Bronchoscopic Navigation (VBN). This research aims to evaluate the clinical benefits of introducing an additional pre-procedure planning system in assigning the optimal FM positions. The objectives are 1) To improve the FMs implantation process by reducing the duration of implantation and radiation exposure to patients, and increasing the number of FMs implanted; 2) to improve FMs stabilities by increasing the FMs usage rate in RT planning and the retention rate at first treatment; reducing the relative migration of the FMs configuration.en_US
dcterms.abstractMethods and Materials: 32 patients were recruited and divided into two groups. 18 patients of Group 1 underwent VBN FMs implantation without pre-procedure planning, 14 patients of Group 2 underwent additional pre-procedure planning. The steps of pre-procedure planning include 1) importing CT images into the treatment planning system (Eclipse, Varian Medical System, Inc.) and delineating five to six FMs in their ideal virtual positions. 2) copy the FM configuration into VBN planning software (LungPoint Bronchus Medical, Inc.) for verification and simulation. Finally, the verified FMs were deployed through VBN with the guidance of the LungPoint planning software.en_US
dcterms.abstractResults: 162 FMs were implanted among 35 lesions in 32 patients aged from 37 to 92 (Median=66). 16 males, and 16 females. Results showed that for objective one, the average FM implantation duration was reduced from 41 (SD=2.05) to 23 minutes (SD=1.25), p=0.00; the average radiation exposure in Dose Area Product (DAP) to patients was reduced from 67.4 (SD=14.48) to 25.3 cGy*cm^2 (SD=3.82), p=0.01 (1 tail); and the average number of FMs implanted around the tumour was increased from 4.7 (SD=0.84) to 5.6 (SD=0.76) and the difference was significant. For objective two, the average FMs usage rate in RT planning was increased from 70 (SD=8) to 92% (SD=4), p=0.02 (1 tail); the average retention rate was increased from 41 (SD=6) to 50% (SD=5), but the difference was insignificant with p=0.12, and the relative migration of FMs configuration was reduced from 5.2 to 2.5%, but the difference was also insignificant.en_US
dcterms.abstractConclusion: The pre-procedure planning improves the FMs implantation efficiency by reducing the implantation duration and radiation exposure to patients, and increasing the number of FMs implanted. It also improves the qualities of FMs stability by increasing the FMs usage rate for planning, but no significant improvement in increasing the FMs retention rate and reducing the relative migration of FMs configuration.en_US
dcterms.extentxiv, 67 pages : color illustrationsen_US
dcterms.isPartOfPolyU Electronic Thesesen_US
dcterms.issued2022en_US
dcterms.educationalLevelDHScen_US
dcterms.educationalLevelAll Doctorateen_US
dcterms.LCSHLungs -- Tumors -- Treatmenten_US
dcterms.LCSHCancer -- Radiotherapyen_US
dcterms.LCSHHong Kong Polytechnic University -- Dissertationsen_US
dcterms.accessRightsrestricted accessen_US

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Please use this identifier to cite or link to this item: https://theses.lib.polyu.edu.hk/handle/200/12249