Author: Tang, Chung Ting
Title: Deep learning to reduce scan time and radiation dose in myocardial perfusion imaging SPECT
Advisors: Yoo, Jung Sun (HTI)
Qin, Harry (SN)
Degree: DHSc
Year: 2022
Subject: Heart -- Tomography
Heart -- Radionuclide imaging
Deep learning (Machine learning)
Hong Kong Polytechnic University -- Dissertations
Department: Faculty of Health and Social Sciences
Pages: xvii, 196 pages : color illustrations
Language: English
Abstract: Background
Coronary heart disease (CHD) is the leading cause of morbidity and mortality worldwide and SPECT MPI remains one of the most commonly used diagnostic imaging examinations to assess the function of the heart muscle. Deep Learning is an emerging technology for a wide range of different applications, including computer vision, it uses deep learning network composed of many layers to extract feature from the images. Despite vibrant technological evolution of SPECT in the past decades, issues of prolonged scan time and relatively high radiation dose remain to be resolved.
To propose and evaluate a deep learning-based approach to reduce scan time and radiation dose in MPI SPECT imaging without compromising diagnostic accuracy.
The new DL-based approach was developed to generate full time (FT)/full dose (FD) images from reduced time/low dose images and evaluated for accurate diagnosis as compared with clinical evaluation parameters. Six hundred pairs of stress and rest Tc-99m sestamibi MPI images were collected retrospectively from Queen Elizabeth Hospital in Hong Kong. Simulation of half and one third time/dose dataset were performed by discarding 50% and 66.6% of projections profiles from FT/FD ground truth dataset. A Generative Adversarial Networks with Dual-Domain U-Net Based Discriminators (DUGAN) was used to predict FT/FD SPECT MPI images and compared with other state-of-the-art DL networks. Similarity between DL synthesized images and standard FT/FD images was evaluated using various metrics, i.e., maximum absolute error (MAE), root mean square error (RMSE) and structural similarity index (SSIM). To judge clinical performance, current gold standard parameters, i.e., total perfusion deficit (TPD), perfusion defect area (TDA), and perfusion defect extent (TDE), summed rest score (SRS) and summed stress score (SSS) were assessed using clinical nuclear cardiology software
The proposed method demonstrates effectiveness to reduce scan time and radiation dose in MPI SPECT imaging. The generated FT/FD MPI images from the half time/dose images using DUGAN showed superior overall imaging performance achieving the MAE of 0.0042, RMSE of 0.2175, and SSIM of 0.9767 (p ≤ 0.05) for the rest dataset and the MAE of 0.0027, RMSE of 0.1874 and SSIM of 0.9902 (p ≤ 0.05) for the stress dataset. The results from the clinical evaluation also proved that the synthesized FT/FD images from the half time/dose images could provide similar clinical performance with the ground truth standard FT/FD images both for the rest and stress datasets (Pearson correlation coefficient of 0.986 for TPD and 0.991 SRS between the DL predicted images from half time/dose images and the reference standard images with stress MPIs).
Deep learning could transform SPECT MPI into a more efficient and radiation minimized examination. The results presented in this study demonstrates the feasibility of deep learning technique to reduce scan time and radiation dose at least into half of the standard technique in MPI SPECT imaging without compromising clinical imaging performance. This could pave the way for clinical translation to circumvent inherent technical problems of SPECT with long acquisition time and relatively high radiation and unleash the potential of deep learning to revolutionize the clinical practice of SPECT imaging.
Rights: All rights reserved
Access: restricted access

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