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dc.contributorDepartment of Biomedical Engineeringen_US
dc.contributor.advisorRuan, Y. C. Sharon (BME)en_US
dc.creatorDu, Yi-
dc.identifier.urihttps://theses.lib.polyu.edu.hk/handle/200/12933-
dc.languageEnglishen_US
dc.publisherHong Kong Polytechnic Universityen_US
dc.rightsAll rights reserveden_US
dc.titleEffects of high fat diet on the mouse model of pancreatic islet β cells specific knockout of Scnn1α.en_US
dcterms.abstractThe prevalence of obesity worldwide is closely related to the rapid growth of diabetes. Statistics show that by 2045, the number of diabetes patients will exceed 7 million(Mann et al., 2023). At present, the most important way to treat diabetes is to inject insulin through subcutaneous injection, but glucose metabolism is very complicated in the body, and the pathogenesis of diabetes is also diverse, so no single treatment will fundamentally alleviate the diabetes pandemic. Diabetes always associates with cardiovascular and kidney disease which caused by salt-water balance. ENaC is a kind of Na+ channel, which has a strong correlation with diabetes related genes such as GIPR, and has a strong influence on salt water hemoestasis in the body. Therefore, we wanted to investigate whether ENaC has a direct effect on the function of pancreatic islet β cells in obesity induced diabetes. Here we established a mouse model of obesity induced diabetes by high fat diet (HFD) and specifically knockout the Scnn1α gene to investigate the potential function. On this basis, glucose tolerance test, plasma insulin level and morphological change of pancreatic islet β cells in mice were compared and analyzed. The results show that the knockout of Scnn1α can help male mice resist the damage of pancreatic islet β cell function caused by diabetes in HFD condition.en_US
dcterms.extent46 pages : color illustrationsen_US
dcterms.isPartOfPolyU Electronic Thesesen_US
dcterms.issued2024en_US
dcterms.educationalLevelM.Sc.en_US
dcterms.educationalLevelAll Masteren_US
dcterms.LCSHDiabetes -- Animal modelsen_US
dcterms.LCSHPancreatic beta cellsen_US
dcterms.LCSHDiabetes -- Treatmenten_US
dcterms.LCSHHong Kong Polytechnic University -- Dissertationsen_US
dcterms.accessRightsrestricted accessen_US

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