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dc.contributorDepartment of Biomedical Engineeringen_US
dc.creatorLi, Jiahao-
dc.identifier.urihttps://theses.lib.polyu.edu.hk/handle/200/12975-
dc.languageEnglishen_US
dc.publisherHong Kong Polytechnic Universityen_US
dc.rightsAll rights reserveden_US
dc.titleA double-decker abdominal window for long-term and real-time high-speed photoacoustic microscopic imaging of hepatic lobulesen_US
dcterms.abstractThe liver is an essential digestive, immune, and endocrine organ that retains one of the most unique vascular structures of the body. The variations in the morphology and physiology of these hepatic vessels, especially the hepatic sinuses, may show the signs of lesions of the liver which may provide more diagnostic information with higher accuracy. Since the photoacoustic imaging modality has the potential to visualize the vascular structures and the hematologic metabolisms, anatomical, functional, and molecular imaging by using photoacoustic microscopy (PAM) on the liver could be one of the obvious choices. Due to the scattering effect and the low penetration of the visible laser in tissues and organs, the abdominal window is required for liver PAM imaging in mice. This article will introduce a double-decker structural abdominal window that could physically fix the liver during the imaging process to improve the quality of PAM imaging by minimizing the motion artifacts. The double-decker structural abdominal window would be suitable for most of the hepatic disease models and also provide long-term imaging to visualize the morphological and physiological changes of hepatic lobules with high resolution. Also, a foundational high-speed PAM imaging system based on galvanometer scanning would be built up to perform real-time imaging to monitor the dynamics of the hepatic sinuses.en_US
dcterms.extentiii, 32 pages : color illustrationsen_US
dcterms.isPartOfPolyU Electronic Thesesen_US
dcterms.issued2024en_US
dcterms.educationalLevelM.Sc.en_US
dcterms.educationalLevelAll Masteren_US
dcterms.LCSHLiver -- Diseases -- Imagingen_US
dcterms.LCSHDiagnostic imagingen_US
dcterms.LCSHHong Kong Polytechnic University -- Dissertationsen_US
dcterms.accessRightsrestricted accessen_US

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Please use this identifier to cite or link to this item: https://theses.lib.polyu.edu.hk/handle/200/12975