Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor | School of Fashion and Textiles | en_US |
| dc.contributor.advisor | Wang, Xungai (SFT) | en_US |
| dc.contributor.advisor | Kan, Chi-wai (SFT) | en_US |
| dc.creator | Lui, Kam Che | - |
| dc.identifier.uri | https://theses.lib.polyu.edu.hk/handle/200/13250 | - |
| dc.language | English | en_US |
| dc.publisher | Hong Kong Polytechnic University | en_US |
| dc.rights | All rights reserved | en_US |
| dc.title | Screen-printed silicone-compression garment composite for hypertrophic scar treatment | en_US |
| dcterms.abstract | Pressure garment treatment (PGT) and silicone gel sheeting (SGS) represent major first-line non-invasive methods for scar healing, each with its own set of advantages and drawbacks. Pressure garments therapy and silicone dressings lack occlusive characteristics and moisture balance. Challenges of non-invasive modalities integration exist in the drawbacks of silicone non-breathability, high tension, and low mechanical properties. Prolonged scar maturation to a decade and the lack of an up-to-date optimum treatment method demand multi-functional composites with compression-silicone dual therapy. | en_US |
| dcterms.abstract | The development of PGF-Biopor®AB addresses these challenges by offering multi-therapeutic benefits, including pressure garment treatment-silicone gel sheeting (PGT-SGS) dual therapy, mechanotherapy, and active moisture management while ensuring dressing performance improvement in uniform adherence and trauma-free dressing removal. A self-pumping dressing in PGF-Biopor®AB features a microchannel structure of nylon absorbency and active compression, the fabrication of controlling viscosity, textile structure, and precise deposition for Biopor®AB solves challenges with multiple therapeutic effects. | en_US |
| dcterms.abstract | This study establishes a clear framework from self-pumping composite design to performance evaluation. For fabrication, the use of pre-strained screen printing with biaxial tensioning creates a "warp insertions" mobility design. The pressure-driven "warp insertions" shifting and Biopor®AB viscoelasticity demonstrate self-pumping to enable compression, mechanotherapy, and pressure redistribution. The Biopor®AB-exposure by PGF-embedding facilitates SGS therapy and achieves uniform adherence and trauma-free dressing removal. The construction of screen-mark microchannels and a “ spiral-through-the-thickness” structure creates an asymmetric 3D channel structure and builds effective unidirectional transport pathways that solve the problem of silicone non-breathability. Under the operation of self-pumping, the Biopor®AB-nylon material characteristics provide an engine of active transport. The pressure-driven active nylon absorbency in the warp insertion mobility design enhances water uptake and enhances water vapour transmission rate for active moisture management. The textile-reinforcement composite making structurally enhances the mechanical properties (tensile and shear), and the biaxial-tensioning introduces stress-strain variations for their tunability, enabling mechanotherapy. In property-performance evaluation, this PGF-inlaid with “warp insertions” mobility demonstrates compression therapy and eliminates the drawback of high tension and low water permeability. The realization of multiple therapeutic performances in PGT-SGS dual therapy, mechanotherapy and dynamic active moisture management made it a functional all-in-one scar-healing dressing. | en_US |
| dcterms.abstract | The integration of PGF and Biopor®AB in a composite achieves PGT-SGS dual therapy, mechanotherapy, and active moisture management for all-in-one scar therapeutics. In contrast to the water permeability of commercial SGS dressing Cica-Care© (12.75 g/m2 per day), PGF-Biopor®AB reveals promising improvements in water uptake (13%) and close-to-skin (223.33 g/m2 per day) water permeability, meeting the scar therapeutic requirements of active moisture management. In the scar-healing performance assessments of cytotoxicity and patient studies, PGF-Biopor®AB demonstrates over 70% cell viability in 3-day sustainability for its continuous safety use, and the 7-day healing of a non-healed wound and one-month efficacy in scarring tissues, all support the multi-therapeutic roles of an ideal scar-healing dressing. Although this work displays a scar-healing dressing material with multiple therapeutics, including compression-silicone dual therapy, active moisture management, and mechanotherapy, it has certain limitations. One such limitation is the formulation restriction of Biopor®AB, necessitating further exploration for lower viscosity options or upscale manufacturing with industrial Octopus printing machines. | en_US |
| dcterms.abstract | Note: This is the final version submitted by the graduate with approval. | en_US |
| dcterms.extent | xiv, 203 pages : color illustrations | en_US |
| dcterms.isPartOf | PolyU Electronic Theses | en_US |
| dcterms.issued | 2024 | en_US |
| dcterms.educationalLevel | Ph.D. | en_US |
| dcterms.educationalLevel | All Doctorate | en_US |
| dcterms.LCSH | Hypertrophic scars -- Care | en_US |
| dcterms.LCSH | Pressure suits -- Therapeutic use | en_US |
| dcterms.LCSH | Textile fabrics -- Therapeutic use | en_US |
| dcterms.LCSH | Hong Kong Polytechnic University -- Dissertations | en_US |
| dcterms.accessRights | open access | en_US |
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