Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor | Department of Computing | en_US |
| dc.contributor.advisor | You, Jane (ISE) | en_US |
| dc.creator | Li, Bowen | - |
| dc.identifier.uri | https://theses.lib.polyu.edu.hk/handle/200/14593 | - |
| dc.language | English | en_US |
| dc.publisher | Hong Kong Polytechnic University | en_US |
| dc.rights | All rights reserved | en_US |
| dc.title | A study and application of automated exosome extraction and concentration system | en_US |
| dcterms.abstract | Extracellular vesicles (EVs) are crucial for intercellular communication and are involved in the development of cancer, cardiovascular, and metabolic diseases. They hold potential as diagnostic biomarkers, therapeutic agents, and medicine carriers. Vesicles from edible plants have shown anti-tumor effects and are easy to obtain. However, the industrialization of exosomes requires efficient methods for their extraction, concentration, and purification. This study presents the development of an automated exosome extraction and concentration system, including the design of hardware and software, prototype manufacturing, and performance evaluation. The system successfully extracted exosomes from human adipose-derived stem cells and plant extracts, showing superior performance to traditional methods. Additionally, a micro-chip was developed for the precise and automated extraction and purification of small amounts of exosomes. The findings offer practical solutions to several technical challenges in the exosome industrialization process. By developing the systems and micro-chips that outperform traditional methods, this study provides a robust framework that could accelerate the adoption and scalability of exosome technologies in clinical and industrial applications. | en_US |
| dcterms.extent | 53 pages : color illustrations | en_US |
| dcterms.isPartOf | PolyU Electronic Theses | en_US |
| dcterms.issued | 2026 | en_US |
| dcterms.educationalLevel | Eng.D. | en_US |
| dcterms.educationalLevel | All Doctorate | en_US |
| dcterms.accessRights | restricted access | en_US |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 9081.pdf | For All Users (off-campus access for PolyU Staff & Students only) | 1.57 MB | Adobe PDF | View/Open |
Copyright Undertaking
As a bona fide Library user, I declare that:
- I will abide by the rules and legal ordinances governing copyright regarding the use of the Database.
- I will use the Database for the purpose of my research or private study only and not for circulation or further reproduction or any other purpose.
- I agree to indemnify and hold the University harmless from and against any loss, damage, cost, liability or expenses arising from copyright infringement or unauthorized usage.
By downloading any item(s) listed above, you acknowledge that you have read and understood the copyright undertaking as stated above, and agree to be bound by all of its terms.
Please use this identifier to cite or link to this item:
https://theses.lib.polyu.edu.hk/handle/200/14593