Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Health Technology and Informatics | en_US |
dc.creator | Chan, Kin-ping | - |
dc.identifier.uri | https://theses.lib.polyu.edu.hk/handle/200/2035 | - |
dc.language | English | en_US |
dc.publisher | Hong Kong Polytechnic University | - |
dc.rights | All rights reserved | en_US |
dc.title | The effects of Chinese herbal medicines on the crystallization of calcium oxalate in an in-vitro artificial crystalliser and by 96-well plate oxalate induced turbidity method | en_US |
dcterms.abstract | The aim of this study was to examine the effects of Herba Lysimachiae (金錢草) and Folium Pyrrosiae (石葦) on the nucleation and growth of calcium oxalate crystals by continuous flow crystallizer system called Mixed Suspension and Mixed Product Removal (MSMPR) and by oxalate induced turbidity method. In this study, concentrated powder form of the herbs was used to make three different concentrations which are 1.0 g/L, 0.5 g/L and 0.1 g/L. The results by the MSMPR demonstrated that Herba Lysimachiae had a strong inhibitory effect on the growth rate of calcium oxalate crystals under the testing concentrations and it also promoted the nucleation rate of calcium oxalate crystals. Folium Pyrrosiae was shown to have an inhibitory effect on crystal growth rate and promoting nucleation only in high concentration (1.0 g/L), the change in nucleation and growth rate were not remarkable at lower concentrations (0.5 g/L and 0.1 g/L). The nucleation rate and growth rate of calcium oxalate crystals were measured from the crystal growth kinetic equation with input of the crystal size distribution acquired from the Coulter Multi-sizer. The results of the oxalate induced turbidity method showed that the nucleation rate of calcium oxalate crystals was found to be increased at all concentrations of Herb Lysimachiae and Folium Pyrrosiae. Increasing nucleation rate of calcium oxalate crystals can decrease the concentration of the salt in urine to a level below the supersaturation state and further crystals cannot form when the concentration of salt is below the supersaturation level. The smaller crystals formed can be passed out with urine easily as they do not get obstructed in the renal tubules, the crystals may get obstructed when their size is bigger. On the other hand, decreasing the growth rate of calcium oxalate crystals can prevent from the formation of crystals large enough to get obstructed in the renal tubules; crystals getting obstructed in the renal tubules can predispose to the formation of renal stone. The results showed that Herba Lysimachiae and Folium Pyrrosiae may be effective in the treatment or prevention of renal stone disease by increasing the nucleation rate and inhibiting the growth of calcium oxalate crystals. | en_US |
dcterms.extent | ix, 92 leaves : ill. ; 30 cm. | en_US |
dcterms.isPartOf | PolyU Electronic Theses | en_US |
dcterms.issued | 2006 | en_US |
dcterms.educationalLevel | All Master | en_US |
dcterms.educationalLevel | M.Sc. | en_US |
dcterms.LCSH | Hong Kong Polytechnic University -- Dissertations. | en_US |
dcterms.LCSH | Kidneys -- Calculi -- Prevention. | en_US |
dcterms.LCSH | Kidneys -- Calculi -- Treatment. | en_US |
dcterms.LCSH | Medicine, Chinese. | en_US |
dcterms.LCSH | Herbs -- Therapeutic use. | en_US |
dcterms.accessRights | restricted access | en_US |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
b2174225x.pdf | For All Users (off-campus access for PolyU Staff & Students only) | 9.1 MB | Adobe PDF | View/Open |
Copyright Undertaking
As a bona fide Library user, I declare that:
- I will abide by the rules and legal ordinances governing copyright regarding the use of the Database.
- I will use the Database for the purpose of my research or private study only and not for circulation or further reproduction or any other purpose.
- I agree to indemnify and hold the University harmless from and against any loss, damage, cost, liability or expenses arising from copyright infringement or unauthorized usage.
By downloading any item(s) listed above, you acknowledge that you have read and understood the copyright undertaking as stated above, and agree to be bound by all of its terms.
Please use this identifier to cite or link to this item:
https://theses.lib.polyu.edu.hk/handle/200/2035