| Author: | Ng, Man-hay |
| Title: | Expression of toll-like receptors 1-9, CK7, CK19 and glypican3 in liver neoplasms |
| Degree: | M.Sc. |
| Year: | 2010 |
| Subject: | Hong Kong Polytechnic University -- Dissertations Liver -- Cancer Liver metastasis Cell receptors -- Diagnostic use Immunohistochemistry |
| Department: | Department of Health Technology and Informatics |
| Pages: | vii, 104 leaves : col. ill. ; 31 cm. |
| Language: | English |
| Abstract: | Toll like receptors (TLRs) have been showed in various types of tissues which mediate innate and adaptive immune response against particular types of pathogen-associated molecular patterns (PAMPs) from micro-organisms. TLRs are involved in many human diseases and cancers. In the 1iver, TLRs had been shown in hepatitis infection, cirrhosis and alcoholic liver diseases etc. In cancer, previous findings suggested the dual role of TLRs-tumor-promoting or anti-tumor. In this experiment, expression of TLRs1-9 in nonnal and malignant livers was investigated by immunohistochemistry. We observed that nonnal liver had the highest frequencies of TLRs1-9 expression among non-neoplastic livers, cirrhotic livers and malignant livers. However, no significant differences in frequencies of TLRs expression were observed between non-neoplastic and cancers; non-neoplastic and cirrhotic livers; and cirrhotic livers and cancers. Moreover, hepatitis B infection status and the presence of oncofeta1 protein glypican3 showed no significant difference of TLRs expression in hepatocellular caccinoma. The decreased frequencies of TLRs expression in liver cancer indicated the failure of TLRs-mediated immune response against tumor cells and might contribute to hepatocarcinogenesis, thus highlighted the potential anti-tumor effect of TLRs in liver tumors. |
| Rights: | All rights reserved |
| Access: | restricted access |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| b23559433.pdf | For All Users (off-campus access for PolyU Staff & Students only) | 7.91 MB | Adobe PDF | View/Open |
Copyright Undertaking
As a bona fide Library user, I declare that:
- I will abide by the rules and legal ordinances governing copyright regarding the use of the Database.
- I will use the Database for the purpose of my research or private study only and not for circulation or further reproduction or any other purpose.
- I agree to indemnify and hold the University harmless from and against any loss, damage, cost, liability or expenses arising from copyright infringement or unauthorized usage.
By downloading any item(s) listed above, you acknowledge that you have read and understood the copyright undertaking as stated above, and agree to be bound by all of its terms.
Please use this identifier to cite or link to this item:
https://theses.lib.polyu.edu.hk/handle/200/5813