Author: Law, Kwok-sing Ricky
Title: Ultrasound measurement of abdominal fat index for predicting cardiovascular disease
Degree: M.Sc.
Year: 2011
Subject: Hong Kong Polytechnic University -- Dissertations
Cardiovascular system -- Diseases -- Diagnosis
Ultrasonic imaging
Department: Department of Health Technology and Informatics
Pages: x, 66 p. : ill. (some col.) ; 30 cm.
Language: English
Abstract: Haemodialysis patients have a higher risk for different cardiovascular diseases including coronary artery disease and carotid atherosclerosis, which are the leading causes for the morbidity and mortality in these patients. It has been reported that visceral fat accumulation is strongly associated with cardiovascular diseases in the general population. Therefore, increased visceral fat may be a useful indicator of increased risk of cardiovascular diseases. Ultrasound has been found to be useful in the quantification of visceral fat by measuring the subcutaneous (S) and preperitoneal fat thickness (P), and expressing as the abdominal fat index (AFI=P/S). However, a recent study reported that the mesenteric fat thickness had a stronger association with carotid atherosclerosis when compared to the subcutaneous and preperitoneal fat thickness. Therefore, the purpose of the present study was to establish a new AFI by including the mesenteric fat thickness (M) in the visceral fat quantification. A total of 40 haemodialysis patents were recruited in the present study (27 men; 13 women; mean age = 58.9 years). Each patient had an abdominal ultrasound (US) and computed tomography (CT) examinations. The visceral fat area (V) and subcutaneous fat area (S) were measured in CT, whilst the mesenteric, preperitoneal and subcutaneous fat thicknesses were measured in US. The CT visceral fat assessment was determined by established method (V/S ratio). Each patient also had a cardiac CT examination to evaluate the coronary calcium score. Result showed that in the US visceral fat assessment the AFI calculated by the equation, AFI = (M/S) x (P/S) showed the highest correlation with the V/S ratio from CT (r=0.69, p<0.05) and with the coronary calcium score from CT (r= 0.51, p<0.05). In conclusion, the new AFI = (M/S) x (P/S) may be a useful indicator of the regional fat distribution in the assessment of cardiovascular disease, and may be useful as an alternative method for predicting cardiovascular disease in haemodialysis patients.
Rights: All rights reserved
Access: restricted access

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