Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor | Department of Health Technology and Informatics | en_US |
| dc.creator | Liang, Xiaozhe | - |
| dc.identifier.uri | https://theses.lib.polyu.edu.hk/handle/200/6238 | - |
| dc.language | English | en_US |
| dc.publisher | Hong Kong Polytechnic University | - |
| dc.rights | All rights reserved | en_US |
| dc.title | Alterations of Endothelin-1 expression in rat's abdominal aorta in response to the changes of blood pressure | en_US |
| dcterms.abstract | Background: Hypertension is a clinical syndrome of continuous elevated arterial pressure. Tissue remodeling of blood vessel is one underlying mechanism responsible for hypertension. Previous researches have suggested that the augmented Endothelin-1 (ET-1) synthesis and expression could involve in vascular remodeling of hypertension. In hypotension, media and adventitia thickness of blood vessel wall are decreased. However, the relationship between ET-1 expression and the raising or lowering of blood pressures is unclear. Objective: To reveal the quantitative relationship between raising or lowering blood pressures and the changes of ET-1 expression by western blot technique. Methodology: In this study, rat's abdominal aorta was clamped to create the raising and lowering of blood pressures. The protein expressions of ET-1 were examined by western blot quantitatively. Finally, a mathematical model was developed to depict quantitative relationship between blood pressure and ET-1. Results: The protein expressions of ET-1 were increased over 20 days in response to elevated blood pressure (P<0.05) and decreased among abdominal aorta samples under the condition of lowering blood pressure (P<0.05). The overall protein expression of ET-1 in rising pressure part was augmented compared with the one in lower pressure part (P<0.05). Conclusion: ET-1 expression is augmented in the state of elevated blood pressure, while ET-1 expression is reduced in response to the lowering of blood pressure. The protein expression of ET-1 is parallel with blood pressure. | en_US |
| dcterms.extent | vi, 39 leaves : ill. ; 30 cm. | en_US |
| dcterms.isPartOf | PolyU Electronic Theses | en_US |
| dcterms.issued | 2011 | en_US |
| dcterms.educationalLevel | All Master | en_US |
| dcterms.educationalLevel | M.Sc. | en_US |
| dcterms.LCSH | Hypertension. | en_US |
| dcterms.LCSH | Endothelins. | en_US |
| dcterms.LCSH | Hong Kong Polytechnic University -- Dissertations | en_US |
| dcterms.accessRights | restricted access | en_US |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| b24578782.pdf | For All Users (off-campus access for PolyU Staff & Students only) | 1.3 MB | Adobe PDF | View/Open |
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