Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor | Department of Health Technology and Informatics | en_US |
| dc.creator | Chan, Shui Yi | - |
| dc.identifier.uri | https://theses.lib.polyu.edu.hk/handle/200/7114 | - |
| dc.language | English | en_US |
| dc.publisher | Hong Kong Polytechnic University | - |
| dc.rights | All rights reserved | en_US |
| dc.title | Assessment of matrix metalloproteinase-9 activity in metabolic syndrome | en_US |
| dcterms.abstract | The prevalence of the metabolic syndrome is increasing worldwide. The syndrome is associated with the cardiovascular risk with an increased morbidity and mortality. A pathophysiological mechanism responsible for the increased risk has not been elucidated. Abnormal MMP-9 activity, which contributes to pathological vascular remodeling, may be one of the components linking the metabolic syndrome to the development of cardiovascular disease. In this project, the alteration of MMP-9 activity on patient with metabolic syndrome and their association with metabolic syndrome component were studied. In our study, no significant difference of total level of free MMP-9 level was found between subjects with and without metabolic syndrome. No correction was found among the total level of free MMP-9 and the components of the metabolic components including the level of glucose, triglyceride, blood pressure, HDL and waist circumference, but significant difference of total level of free MMP-9 was found between the aged group and the young group of the subject. In conclusion, no difference on the total level of free MMP-9 was shown in metabolic syndrome patient compared with healthy subjects. The increased total level of free MMP-9 found in aged group might suggest a possibly relevant pathophysiological mechanism that involved in the increase of cardiovascular risk associated with aging. | en_US |
| dcterms.extent | viii, 77 leaves : ill. ; 30 cm. | en_US |
| dcterms.isPartOf | PolyU Electronic Theses | en_US |
| dcterms.issued | 2013 | en_US |
| dcterms.educationalLevel | All Master | en_US |
| dcterms.educationalLevel | M.Sc. | en_US |
| dcterms.LCSH | Metabolic syndrome. | en_US |
| dcterms.LCSH | Metalloproteinases. | en_US |
| dcterms.LCSH | Extracellular matrix proteins. | en_US |
| dcterms.LCSH | Hong Kong Polytechnic University -- Dissertations | en_US |
| dcterms.accessRights | restricted access | en_US |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| b26370992.pdf | For All Users (off-campus access for PolyU Staff & Students only) | 436.74 kB | Adobe PDF | View/Open |
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