Full metadata record
DC FieldValueLanguage
dc.contributorDepartment of Health Technology and Informaticsen_US
dc.creatorNg, Yue Hum Fantas-
dc.identifier.urihttps://theses.lib.polyu.edu.hk/handle/200/7341-
dc.languageEnglishen_US
dc.publisherHong Kong Polytechnic University-
dc.rightsAll rights reserveden_US
dc.titleAssessment of melatonin and its association with sleep in metabolic syndromeen_US
dcterms.abstractAccording to World Health Organization (WHO), there were 17.3 million people died from cardiovascular disease (CVD) in 2008 worldwide and currently there were 347 million people affected by diabetes mellitus (DM). The prevalence of CVD and DM was increasing in an alarming rate and both risk factors were associated with metabolic syndrome (MS). Metabolic syndrome was a combination of metabolic abnormalities including dyslipidemia, hyperglycemia, high blood pressure and central obesity. In addition, subjects affected by MS were also associated with sleep deprivation. Shortened sleep time and poor quality of sleep had been shown to cause an increase in food intake and higher blood pressure which were the risk factors associated with MS. In Hong Kong, the prevalence of MS was increasing from 9.6% in 1990s to 23% in 2001. This surge of MS required immediate attention and quicker method to diagnose MS was needed to stop the uprising of MS in the future. Melatonin had been shown to promote sleep and curtail MS. By evaluating melatonin levels with subjects with and without MS may provide a quicker mean of predicting MS. The objective of this study was to evaluate sleep biomarker, melatonin and its association with sleep in a total of forty Hong Kong Chinese subjects with and without MS. Enzyme-linked immunosorbent assay (ELISA) was used to measure the plasma melatonin concentration and Pittsburgh Sleep Quality Index (PSQI) questionnaires were used to evaluate the sleep quality and sleep duration for all the study subjects.en_US
dcterms.abstractSubjects with MS had significant lower levels of melatonin than subjects without MS (4.06±0.47 versus 6.10±0.45, p=0.003) as expected since melatonin helped with curtailing MS and subjects with MS had been shown to have lower circulating melatonin. There was a positive correlation between melatonin levels and High-Density Lipoprotein Cholesterol (HDL) with p=0.04. However there was no significant difference between quality of sleep and duration of sleep with melatonin levels for this study (p=0.415 and p=0.101). There was also no significant difference between quality of sleep and duration of sleep while comparing to subjects with and without MS (p=0.324 and p=0.206). Lower plasma melatonin levels in MS subjects suggested melatonin may involve with pathogenesis of MS. Melatonin therapy had been shown to help subjects with MS to decrease blood pressures, lose weight and improve lipid profile. The reason for no significant difference between sleep quality, sleep duration and melatonin level may be due to limitation of this study. The optimal way to evaluate melatonin levels was before going to bed and after waking up. The best way to evaluate sleep was using sleep actigraphs or full polysomnography. Numerous clinical trials had examined the therapeutic values of melatonin in various diseases such as cardiovascular diseases, diabetes and sleep disturbances but no clinical trial had been done to use melatonin as biomarker to predict MS. More clinical trials with larger population would be needed to investigate melatonin involvement in MS and found the definite pathophysiologic role in human.en_US
dcterms.extentx, 75 leaves : ill. ; 30 cm.en_US
dcterms.isPartOfPolyU Electronic Thesesen_US
dcterms.issued2014en_US
dcterms.educationalLevelAll Masteren_US
dcterms.educationalLevelM.Sc.en_US
dcterms.LCSHMelatonin -- Physiological effect.en_US
dcterms.LCSHSleep.en_US
dcterms.LCSHMetabolic syndrome.en_US
dcterms.LCSHHong Kong Polytechnic University -- Dissertationsen_US
dcterms.accessRightsrestricted accessen_US

Files in This Item:
File Description SizeFormat 
b26753807.pdfFor All Users (off-campus access for PolyU Staff & Students only)1.54 MBAdobe PDFView/Open


Copyright Undertaking

As a bona fide Library user, I declare that:

  1. I will abide by the rules and legal ordinances governing copyright regarding the use of the Database.
  2. I will use the Database for the purpose of my research or private study only and not for circulation or further reproduction or any other purpose.
  3. I agree to indemnify and hold the University harmless from and against any loss, damage, cost, liability or expenses arising from copyright infringement or unauthorized usage.

By downloading any item(s) listed above, you acknowledge that you have read and understood the copyright undertaking as stated above, and agree to be bound by all of its terms.

Show simple item record

Please use this identifier to cite or link to this item: https://theses.lib.polyu.edu.hk/handle/200/7341