| Author: | Teng, Yun |
| Title: | Graphene quantum dots : magnetic nanoparticle composite based cellular drug delivery carrier system |
| Degree: | M.Sc. |
| Year: | 2014 |
| Subject: | Quantum dots. Graphene. Nanomedicine. Hong Kong Polytechnic University -- Dissertations |
| Department: | Interdisciplinary Division of Biomedical Engineering |
| Pages: | xv, 76 leaves : color illustrations. ; 30 cm |
| Language: | English |
| Abstract: | Recently, the functionalized graphene quantum dots has more attention because of their multifunctional properties concern, just like high surface area, low toxicity and good stability. Graphene quantum dots can in some cases be used as nano-drug itself. Therefore, it is considered to be a great potential for drug delivery applications, diagnosis, treatment, and sensing, in particular controlled, because they are installed and to maintain potency of the drug release rate of the drug delivery system over the fixedly. While functionalized graphene nano systems can produce an unbelievable promotion in nano medicine filed. Not only to carry the drug, drug delivery and controlling the drug efficiency in the drug delivery process. the tracking and evaluation of visualization. As for magnetic nanoparticals, research on magnetic nanoparticles has been a very active area of research people, because there are many important applications. for example: drug delivery, imaging and hyperthermia. Hyperthermia has been used for many years for the treatment of cancer and various patients. which that at 42 ~ 45°C. the tumor cells are necrotic, charring or coagulation. In addition. the cells are more sensitive than the normal at this temperature range. In this experiment, we synthesis of GQD and MNP through EDC/NHS reaction, and we calculated the quality GQD on GQD-MNP composite. We conclude that the FA-GQD-MNP can get into cell faster to produce stronger blue fluorescence through the imaging of cellular uptake and the fluorescence intensity of comparison among GQD, GQD-MNP and FA-GQD-MNP. In addition, we try to demonstrate the influence of adding local concentration for cellular uptake. We demonstrate that adding local concentration can promote the cellular uptake of FA-GQD-MNP composites through the magnetic attraction experiment. Through the cytotoxicity assessment. we conclude that FA-GQD-MNP composite has lower cytotoxicity than pure GQD and GQD-MNP; it indicates that FA-GQD-MNP has the potential to carry drugs for selectively killing cancer cells in vitro. |
| Rights: | All rights reserved |
| Access: | restricted access |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| b27577417.pdf | For All Users (off-campus access for PolyU Staff & Students only) | 26.6 MB | Adobe PDF | View/Open |
Copyright Undertaking
As a bona fide Library user, I declare that:
- I will abide by the rules and legal ordinances governing copyright regarding the use of the Database.
- I will use the Database for the purpose of my research or private study only and not for circulation or further reproduction or any other purpose.
- I agree to indemnify and hold the University harmless from and against any loss, damage, cost, liability or expenses arising from copyright infringement or unauthorized usage.
By downloading any item(s) listed above, you acknowledge that you have read and understood the copyright undertaking as stated above, and agree to be bound by all of its terms.
Please use this identifier to cite or link to this item:
https://theses.lib.polyu.edu.hk/handle/200/7556