Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor | Department of Health Technology and Informatics | en_US |
| dc.contributor.advisor | Siu, Gilman (HTI) | - |
| dc.creator | Ma, Chi Wah Jerry | - |
| dc.identifier.uri | https://theses.lib.polyu.edu.hk/handle/200/7906 | - |
| dc.language | English | en_US |
| dc.publisher | Hong Kong Polytechnic University | - |
| dc.rights | All rights reserved | en_US |
| dc.title | Evaluation of direct detection of mycobacterium tuberculosis complex in extra-pulmonary clinical specimens with Cepheid Genexpert platform | en_US |
| dcterms.abstract | Extrapulmonary tuberculosis (EPTB) is considered a major clinical problem and has been noted to have significantly increased worldwide, especially in industrialized countries, which accounts for approximately 20% of Tuberculosis (TB) cases. Xpert MTB/RIF has been proven to be an excellent point-of-care platform to diagnose pulmonary TB in highly endemic countries with a fully automatic molecular system. In this study, we aimed to investigate the ability of the Xpert system to detect extrapulmonary tuberculosis in Hong Kong. We included 231 extrapulmonary clinical samples which correspond to 188 patients. By comparing with the gold standard culture method as well as the clinical diagnosis of TB records, an overall sensitivity of 81.8% and specificity of 100% was obtained. For the biopsy specimens, the sensitivity is around 80% while the non-biopsy specimens including the body fluid, pus & urine was 100%. The performance of Xpert is better in the AFB microscopy positive than in the negative sample, with a sensitivity of 100% in the positive compared to 75% in the negative samples. Even though the conventional culture method is still considered the main tool in the diagnosis of extrapulmonary TB, the Xpert system provides an alternative method to screen for EPTB in a more efficient way with higher sensitivity and faster turnaround time compared with smear microscopy. Hence, including traditional culture methods as well as the Xpert as a combo test for the screening of EPTB is recommended. | en_US |
| dcterms.extent | vii, 45 leaves ; 30 cm | en_US |
| dcterms.isPartOf | PolyU Electronic Theses | en_US |
| dcterms.issued | 2015 | en_US |
| dcterms.educationalLevel | All Master | en_US |
| dcterms.educationalLevel | M.Sc. | en_US |
| dcterms.LCSH | Tuberculosis -- Diagnosis | en_US |
| dcterms.LCSH | Mycobacterium tuberculosis -- Diagnosis | en_US |
| dcterms.LCSH | Hong Kong Polytechnic University -- Dissertations | en_US |
| dcterms.accessRights | restricted access | en_US |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| b28001576.pdf | For All Users (off-campus access for PolyU Staff & Students only) | 712.29 kB | Adobe PDF | View/Open |
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