Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor | Department of Health Technology and Informatics | en_US |
| dc.contributor.advisor | Siu, Parco (HTI) | - |
| dc.creator | Au, Ka Ching Kent | - |
| dc.identifier.uri | https://theses.lib.polyu.edu.hk/handle/200/7908 | - |
| dc.language | English | en_US |
| dc.publisher | Hong Kong Polytechnic University | - |
| dc.rights | All rights reserved | en_US |
| dc.title | The effect of habitual exercise-induced Sirt-3 on mitochondrial adaptation in skeletal muscle of rat | en_US |
| dcterms.abstract | Mitochondrial Sirtuin-3 (Sirt-3) is a member of the class III histone deacetylases, which possess nicotinamide adenine dinucleotide (NAD+) dependent deactylase and adenosine diphosphate (ADP) ribosyltransferase activities. In the last decade, Sirt-3 has become a highly promising target for curing mitochondrial disorders. This current study examined the effect of long term habitual exercise on the expression of Sirt-3 in plantaris muscle and its correlation with mitochondrial content indicated by the level of Cytochrome c oxidase subunit-4 (Cox-4) protein. 20-week habitual exercise significantly increased the Sirt-3 expression (P < 0.05) and positively correlated with Cox-4 expression in plantaris muscle (P < 0.05). It indicated that Sirt-3 contributed to mitochondrial biogenesis after long term voluntary exercise. It was surprising to demonstrate that Sirt-3 was significantly correlated with the transformation of muscle fibre form type-IIb/IIx to IIa (P < 0.05). Collectively, prolonged habitual exercise induced Sirt-3 could possibly promote both mitochondrial biogenesis and fibre type transformation. | en_US |
| dcterms.extent | xiii, 97 leaves : illustrations ; 30 cm | en_US |
| dcterms.isPartOf | PolyU Electronic Theses | en_US |
| dcterms.issued | 2015 | en_US |
| dcterms.educationalLevel | All Master | en_US |
| dcterms.educationalLevel | M.Sc. | en_US |
| dcterms.LCSH | Mitochondrial pathology. | en_US |
| dcterms.LCSH | Musculoskeletal system. | en_US |
| dcterms.LCSH | Rats -- Physiology | en_US |
| dcterms.LCSH | Hong Kong Polytechnic University -- Dissertations | en_US |
| dcterms.accessRights | restricted access | en_US |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| b28013633.pdf | For All Users (off-campus access for PolyU Staff & Students only) | 5.09 MB | Adobe PDF | View/Open |
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