|Title:||Magnetic and fluorescent Fe₃O₄@SiO₂-GQDs-FA nanoparticles for simultaneous dual modal imaging and targeted drug delivery|
|Subject:||Drug delivery systems.|
Hong Kong Polytechnic University -- Dissertations
|Department:||Interdisciplinary Division of Biomedical Engineering|
|Pages:||xii, 54 pages : color illustrations|
|Abstract:||The development of nanocarriers with multiple functionalities, e.g. multimodal imaging, medical targeting, diagnostics, and therapeutic actions in one material, has attracted considerable interests for biomedical applications. The use of multifunctional nanocarriers for early diagnosis and therapy of diseases is expected to provide significant improvements to the diagnostic accuracy, therapeutic efficiency and minimize side effects. A novel graphene quantum dots (GQDs) based drug delivery system was developed for dual-model imaging and cancer therapy. Magnetic and fluorescent Fe₃O₄@SiO₂-GQDs-FA nanocarriers were successfully fabricated. Specifically, Fe₃O₄ nanoparticles (NPs) were synthesized via a modified co-precipitation method. Core-shell Fe₃O₄@SiO₂ NPs were fabricated by modifying the Stober method via the hydrolysis of tetraethyl orthosilicate (TEOS). The conjugation of GQDs onto the surfaces of amino functionalized Fe₃O₄@SiO₂ NPs was achieved via the classic carbodiimide crosslinker chemistry. The non-covalent π-π stacking was used to load DOX onto the nanocarriers. Luminescent GQDs allows real-time tracing intracellular uptake, suggesting the localization of internalized nanocarriers. The cytotoxicity data suggest that drug-free nanocarriers are highly biocompatible and DOX-loaded nanocarriers are more effective than free DOX in cancer therapy. As mentioned above, these luminomagnetic nanocarriers with excellent biocompatibility, super fluorescence property and good magnetic response would have potential application in diagnosis and therapy. It is revealed that MNPs@SiO₂-GQD-FA nanocarrier is a promising platform for simultaneous dual modal imaging and targeted drug delivery.|
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